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Multiple colorectal neoplasms in a young adult with hypogammaglobulinemia

Report of a case

  • Case Reports
  • Published:
Diseases of the Colon & Rectum

Abstract

We report on a 22-year-old man with congenital hypogammaglobulinemia who developed multiple colorectal neoplasms. An immunodeficiency had been diagnosed in the patient since two years of age, and this time many tumors of the sigmoid colon and rectum were detected by barium enema and fiberscopy. Abdominoperineal resection was performed, and the resected specimen revealed 29 polyps, including 9 adenocarcinomas and 20 adenomas. The carcinomas, measuring 0.8 to 11.0 cm in size, showed various depths of invasion, and the adenomas, measuring 0.2 to 1.5 cm in size, showed various degrees of epithelial atypia. DNA analysis demonstrated that the tumors were heterogeneous, showing different DNA index and ploidy patterns. The pathogenetic relation between malignancy and immunodeficiency is also reviewed.

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Authors and Affiliations

  1. Second Department of Surgery, Faculty of Medicine, Kyushu University, 3-1-1 Maidashi, Higashi-ku, 812, Fukuoka, Japan

    Yosuke Adachi M.D., Masaki Mori M.D., Akinori Kido M.D., Reishi Shimono M.D., Taketoshi Suehiro M.D. &  Keizo Sugimachi M.D.

Authors
  1. Yosuke Adachi M.D.
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  2. Masaki Mori M.D.
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  3. Akinori Kido M.D.
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  4. Reishi Shimono M.D.
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  5. Taketoshi Suehiro M.D.
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  6. Keizo Sugimachi M.D.
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Cite this article

Adachi, Y., Mori, M., Kido, A. et al. Multiple colorectal neoplasms in a young adult with hypogammaglobulinemia. Dis Colon Rectum 35, 197–200 (1992). https://doi.org/10.1007/BF02050679

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