Diseases of the Colon & Rectum

, Volume 36, Issue 10, pp 908–912 | Cite as

Increased risk of early colorectal neoplasms after hepatic transplant in patients with inflammatory bowel disease

  • Ronald Bleday
  • Edward Lee
  • Jose Jessurun
  • John Heine
  • W. Douglas Wong
Original Contributions
  • 26 Downloads

Abstract

Inflammatory bowel disease (IBD) is associated with an increase in colon and rectal carcinoma. Immunosuppression after transplantation increases the incidence of certain types of tumors. PURPOSE: We reviewed the postoperative course of IBD patients who had undergone hepatic transplantation for primary sclerosing cholangitis to see whether there was an increase in the rate of colorectal neoplasms. METHODS: The charts of 44 patients from two institutions who had undergone a hepatic transplant for primary sclerosing cholangitis were reviewed. Of these 44 patients, 33 had IBD (32 chronic ulcerative colitis, 1 Crohn's). Of these 33 patients, 2 had previously undergone total colectomy/proctectomy and 4 died in the perioperative period. The remaining 27 patients had all undergone colonoscopic evaluation just prior to transplant. Postoperatively all patients were given prednisone, cyclosporine, and azathioprine. Minimum follow-up was 12 months; mean follow-up was 39 months. RESULTS: Three of the 27 patients (11.1 percent) developed early colorectal neoplasms (2 cancers, 1 large villous adenoma with severe dysplasia) at 9, 12, and 13 months post-transplant. All three patients were successfully treated with a total colectomy/proctectomy or resection of any remaining colon. These 3 patients had a mean 19-year history of IBD (range, 9–27 years), while the 24 patients without tumors had a mean 18-year history of IBD (range, 6–39 years). CONCLUSION: There is a subset of transplant patients with primary sclerosing cholangitis and IBD who rapidly develop colorectal neoplasms. Frequent surveillance is recommended for IBD patients in the post-transplant period.

Key words

Hepatic transplant Colitis Neoplasms 

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Copyright information

© American Society of Colon and Rectal Surgeons 1993

Authors and Affiliations

  • Ronald Bleday
    • 1
  • Edward Lee
    • 1
  • Jose Jessurun
    • 2
  • John Heine
    • 3
  • W. Douglas Wong
    • 4
  1. 1.Department of SurgeryNew England Deaconess Hospital, Harvard Medical SchoolBoston
  2. 2.Department of PathologyUniversity of MinnesotaMinneapolis
  3. 3.Department of SurgeryUniversity of CalgaryCalgaryCanada
  4. 4.Division of Colon and Rectal SurgeryUniversity of MinnesotaMinneapolisMinnesota

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