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Mycopathologia et mycologia applicata

, Volume 36, Issue 3–4, pp 322–340 | Cite as

Comparative histopathology of chromomycosis and cladosporiosis in the experiment

  • R. A. Aravysky
  • V. B. Aronson
Article

Conclusions

1. The reaction of the brain tissue and skin in cladosporiosis and chromomycosis (as well as in some other fungal affections) is in many respects similar and is manifested by the formation of microabscesses, containing giant cells, with phagocytized elements of the causative agents. The fungus contained in the cells at the late phase of the experiment retains its viability, which may be the cause of the dissemination of the process when the reactivity of the organism is lowered.

2. The course of cladosporiosis of the brain is characterized by the absence of visible changes of the nerve cells even near the growth of the fungus. The observed edematous changes of neurons in the area of the infiltrations are connected with the foci of the purulent liquefaction of the brain tissue.

3. The tissue form both in chromomycosis and cladosporiosis is a stage of the fungus development independent of the organ which it affects (skin, brain).

4. The predominating involvement of the brain byCladosporium trichoides may be partly due to tis quicker development in the tissue of the skin as compared toHormodendron pedrosoi and to its ability to germinate through the walls of the blood vessesls, resulting in the penetration into their lumen and hematogenic dissemination.

5. Under the conditions of the increased content of glucocorticoids in the organism, the macrophagic and giant cell reaction of the tissues is regularly inhibited, the formation of collagens is disturbed, which results in the generalization of the mycotic process.

Keywords

Collagen Germinate Glucocorticoid Brain Tissue Giant Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Dr. W. Junk N.V. 1968

Authors and Affiliations

  • R. A. Aravysky
    • 1
    • 2
    • 3
  • V. B. Aronson
    • 1
    • 2
    • 3
  1. 1.Institute of Experimental MedicineAcademy of Medical SciencesUSSR
  2. 2.Laboratory of CytologyLeningrad
  3. 3.Dermatologic ClinicI.P. Pavlov Medical InstituteLeningrad

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