Mycopathologia et mycologia applicata

, Volume 54, Issue 3, pp 385–390 | Cite as

Pathogenicity of alternaria alternata and its antibody production in experimental animals

  • B. D. Reddy
  • D. C. Kelley
  • H. C. Minocha
  • H. D. Anthony
Article

Abstract

To determine the potential pathogenicity ofAlternaria alternata, we exposed rabbits and guinea pigs to the organism by intradermal and intraperitoneal injection and by scarification. It caused superficial mycosis when inoculated by scarification. An antigenic extract of it that we prepared and used in ring precipitation tests demonstrated precipitating antibodies in the experimentally infected animals.

Keywords

Precipitation Experimental Animal Mycosis Intraperitoneal Injection Antibody Production 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Ainsley, R. & B. Smith, (1965) Fungal flora of the conjunctival sac in healthy and diseased eyes. Brit. J. Opthol. 49: 505.Google Scholar
  2. 2.
    Baker, R. D. et al. (1971) Human infection with fungi, actinomycetes and algae. Springer-Verlag, New York. P. 1191.Google Scholar
  3. 3.
    Borsook, M. E. (1933) Skin infection due to Alternaria tenuis with the report of a case. Canad. Med. Ass. J. 29: 479.Google Scholar
  4. 4.
    Botticher, W. W. (1966) Alternaria as a possible human pathogen. Sabouraudia 4: 256.PubMedGoogle Scholar
  5. 5.
    Chamot, E. M. & C. W. Mason, (1938) Handbook of Chemical Microscopy, I. New York.Google Scholar
  6. 6.
    Delacretaz, J., D. Grigoriu & A. Grigoriu, (1970) Alternaria tenuis en Cutanee Humaine. Ann. de Dermatologie 97, 1: 15–20.Google Scholar
  7. 7.
    Dovgich, N. A. (1962) Spinal eczema in dogs: A fungal disease. Veterinariya, Moscow. 3: 31–32 (R).Google Scholar
  8. 8.
    English, M. P. (1965) The saprophytic growth of nonkeratinophilic fungi on keratinized substrata and a comparison with keratinophilic fungi. Trans. Brit. Mycol. Soc. 48: 219–235.Google Scholar
  9. 9.
    Henrici, A. T. (1930) Molds, Yeasts and Actinomycetes. John Wiley & Sons, Inc. New York.Google Scholar
  10. 10.
    Hopkins, J. G., R. W. Benham & B. M. Kestin (1930) Asthma due to a fungus Alternaria. J.A.M.A. 94: 6.Google Scholar
  11. 11.
    Hopkins, J. G., R. W. Benham & B. M. Kestin (1929–30) Sensitization to saprophytic fungi in a case of eczema. Proc. Soc. Exp. Biol. Med. 27: 342.Google Scholar
  12. 12.
    Lucas, G. B. (1971) Alternaria alternata (Fries) Keissler, the correct name for A. tenuis and A. longipes. Tob. Sci. 15: 37–42.Google Scholar
  13. 13.
    Miller, W. S. & J. P. Tindall (1967) Presented at Fourteenth Annual Meeting of the Zola Cooper Memorial Clinicopathologic Seminar, Miami, Florida. Nov. 13, 1967.Google Scholar
  14. 14.
    Neergard, P. (1945) Danish Species of Alternaria and Stemphylium. Oxford University Press. London.Google Scholar
  15. 15.
    Ohashi, Y. (1960) On a rare disease due to Alternaria tenuis Nees (Alternariasis). Tohoku J. Exp. Med. 72: 78.PubMedGoogle Scholar
  16. 16.
    Ohue (1930) The Science Reports of the Tohoku University, 5: 117.Google Scholar
  17. 17.
    Schaffer, N. (1960) Mold allergy during the winter months. New York State J. Med. 60, 1: 49–53.Google Scholar
  18. 18.
    Shelley, W. B. & R. Florance (1961) Chronic urticaria due to mold hypersensitivity. Arch. Derm. Chicago 83, 4: 549–558.Google Scholar
  19. 19.
    Simmons, E. G. (1967) Typification of Alternaria, Stemphylium and Ulscladium. Mycologia 59: 73.Google Scholar
  20. 20.
    Thjotta, T. et al. (1950) Preparation of fungus antigens for immunization and for serological reactions. Acta Path. 28: 132–138.Google Scholar

Copyright information

© Dr. W. Junk B.V. 1974

Authors and Affiliations

  • B. D. Reddy
    • 1
    • 2
  • D. C. Kelley
    • 1
  • H. C. Minocha
    • 1
  • H. D. Anthony
    • 1
  1. 1.Department of Infectious Diseases and Veterinary Diagnostic LaboratoryKansas State UniversityManhattan
  2. 2.Veterinary College, HyderabadA.P. Agricultural UniversityHyderabadIndia

Personalised recommendations