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DNA ploidy of colorectal cancer and synchronous polyps in polyposis coli

  • Original Contributions
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Diseases of the Colon & Rectum

Abstract

Sixteen patients with polyposis coli and cancer were studied retrospectively to determine the incidence of DNA ploidy abnormalities in the tumors and synchronous polyps. Six patients (37 percent) had nondiploid tumors. Nondiploid tumors were more likely to be advanced and had a significantly worse prognosis (17 percent vs.76 percent 5-year survival;P <0.01). Only 4 of 20 polyps studied were nondiploid. There was no association between tumor and polyp ploidy. All nondiploid polyps were found in patients with synchronous diploid cancers. Patients with nondiploid polyps were more likely to be older and have more advanced tumors than those with diploid polyps. DNA ploidy abnormalities seem to occur with the same frequency in polyposis coli as in the nonpolyposis population, and tumor ploidy correlates with prognosis

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Authors and Affiliations

  1. Departments of Surgery and Pathology, The Mount Sinai School of Medicine, City University of New York, New York, New York

    Felice Miller M.D., Tomas M. Heimann M.D., Arnold Szporn M.D., Giorgio Martinelli Ph.D., Robert J. Kurtz M.D. & Thomas M. Fasy M.D., Ph.D.

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  1. Felice Miller M.D.
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  2. Tomas M. Heimann M.D.
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  3. Arnold Szporn M.D.
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  4. Giorgio Martinelli Ph.D.
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  5. Robert J. Kurtz M.D.
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  6. Thomas M. Fasy M.D., Ph.D.
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Miller, F., Heimann, T.M., Szporn, A. et al. DNA ploidy of colorectal cancer and synchronous polyps in polyposis coli. Dis Colon Rectum 34, 1103–1108 (1991). https://doi.org/10.1007/BF02050070

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  • DOI: https://doi.org/10.1007/BF02050070

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