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Diseases of the Colon & Rectum

, Volume 34, Issue 7, pp 600–605 | Cite as

Use of photodynamic therapy in the palliation of massive advanced rectal cancer

Phase I/II study
  • Hanoch Kashtan
  • Moshe Z. Papa
  • Brian C. Wilson
  • Alexander A. Deutch
  • Hartley S. Stern
Article

Abstract

Photodynamic therapy (PDT) is a relatively new form of cancer therapy utilizing a photosensitizer such as hematoporphyrin derivative. We conducted a pilot study to determine the efficacy of its use in palliating advanced rectal cancer, to determine toxicity, and to establish objective outcome criteria. Six patients with very advanced, usually recurrent rectal cancer were treated with PDT after being photosensitized with Photofrin II®. A protocol was established to measure clinical and radiologic response to therapy. A new intraluminal delivery system was incorporated. Five patients had both clinical and radiologic responses to therapy. In two patients we observed such significant responses that they cannot be accounted for on a photobiologic basis alone. One patient developed a significant sunburn after discharge. There was no major toxicity of bleeding or sepsis even at maximum doses (200 J/cm2). We are confident that PDT has a role to play in rectal cancer and speculate as to future applications.

Key words

Rectal cancer PDT Palliation 

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Copyright information

© American Society of Colon and Rectal Surgeons 1991

Authors and Affiliations

  • Hanoch Kashtan
    • 1
    • 2
  • Moshe Z. Papa
    • 1
    • 2
  • Brian C. Wilson
    • 1
    • 2
    • 3
  • Alexander A. Deutch
    • 1
    • 2
  • Hartley S. Stern
    • 1
    • 2
  1. 1.Department of SurgeryUniversity of TorontoTorontoCanada
  2. 2.1225 Mt. Sinai HospitalTorontoCanada
  3. 3.Department of BiophysicsMcMaster UniversityTorontoCanada

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