Diseases of the Colon & Rectum

, Volume 36, Issue 6, pp 607–609 | Cite as

Colonic necrosis following sodium polystyrene sulfonate (Kayexalate®)-sorbitol enema in a renal transplant patient

Report of a case and review of the literature
  • Thomas R. Scott
  • Scott M. Graham
  • Eugene J. Schweitzer
  • Stephen T. Bartlett
Case Report


The authors present the case of a patient who developed near total colonic necrosis shortly after renal transplantation. The onset of symptoms was temporally related to the administration of sodium polystyrene (Kayexalate ® ;Sanofi Winthrop Pharmaceuticals, New York, NY)-sorbitol enemas for treatment of hyperkalemia. Three similar cases have been reported in the literature. The presence of uremia and the use of sorbitol appear to be common denominators in the pathophysiology of this complication. It is suggested that Kayexalate ® -sorbitol enemas be avoided in renal transplant patients.

Key words

Colitis Renal transplant Kayexalate® Sorbitol 


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Copyright information

© American Society of Colon and Rectal Surgeons 1993

Authors and Affiliations

  • Thomas R. Scott
    • 1
  • Scott M. Graham
    • 1
  • Eugene J. Schweitzer
    • 1
  • Stephen T. Bartlett
    • 1
  1. 1.Department of Surgery, Sections of Surgical Endoscopy and TransplantationUniversity of Maryland School of MedicineBaltimore

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