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Applications of magnetic resonance spectroscopy to diagnosis and monitoring of mitochondrial disease

  • Workshop “New MR Techniques In Clinical Neurology”
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Abstract

Magnetic resonance spectroscopy (MRS) can now be performed on routine high-field clinical magnetic resonance imaging systems. Over the last decade it has provided several useful insights into the pathophysiology of mitochondrial disorders. More recently, the feasibility of applications to clinical diagnosis and monitoring have been demonstrated. Exciting new work suggests that carefully supervised physical conditioning in conjunction with sodium dichloroacetate administration can markedly enhance both biochemical measures of aerobic metabolism and functional performance of patients with mitochondrial myopathies.

Sommario

La risonanza magnetica spettroscopica (MRS) può oggi essere effettuata di routine in apparecchi clinici di risonanza magnetica. Nell'ultima decade essa ha fornito importanti informazioni nella patofisiologia dei disordini mitocondriali. Più recentemente sono state dimostrate le sue possibilità di applicazione nella diagnosi clinica e nel monitoraggio di pazienti neurologici. Nuovi ed interessanti studi suggeriscono che un allenamento attentamente supervisionato in congiunzione con trattamento con dicloroacetato è capace di migliorare i parametri biochimici e la performance di pazienti con miopatie mitocondriali.

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Authors and Affiliations

  1. Clinical Magnetic Resonance Spectroscopy Laboratory, Dept. of Neurology and Neurosurgery, Montreal Neurological Institute, 3801 University St., Montreal, Canada

    Matthews P. M. & Taivassalo T.

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  1. Matthews P. M.
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  2. Taivassalo T.
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Matthews, P.M., Taivassalo, T. Applications of magnetic resonance spectroscopy to diagnosis and monitoring of mitochondrial disease. Ital J Neuro Sci 18, 341–351 (1997). https://doi.org/10.1007/BF02048237

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