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The191Os/191mIr generator for clinical use

I. Evaluation of potential adsorbents

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Abstract

An evaluation of adsorbents for potential use in the191Os/191mIr medical radionuclide generator was performed. The adsorbents included 39 inorganic materials broadly classified as oxides, antimonates, ferro-ferricyanides, phosphates, sulfides, and miscellaneous including activated carbon and the organic anion-exchanger AGMP-1. The uptake of191Os in oxidation states (VI) [potassium tetrachloroosmate], (IV) [potassium hexachloroosmate] and (III) [potassium hexathiocyanatoosmate] was measured. Adsorbents having a high191Os uptake were evaluated for191mIr elution yield using three physiologically compatible eluents. Only activated carbon and AGMP-1 adsorbents showed significant191mIr elution yields under the test conditions (10% and 37%, respectively). The results of these studies suggest that activated carbon may be a promising adsorbent for development of a new191Os/191mIr medical radionuclide generator. Activated carbon is a good candidate for further development since it is inert to the chemical and radiation effects which may effect an organic based ion exchange material such as AGMP-1.

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Author notes

  1. C. Brihaye

    Present address: Cyclotron Research Center, University of Liege, Liege, Belgium

Authors and Affiliations

  1. Nuclear Medicine Group, Health and Safety Research Division, Oak Ridge National Laboratory, 37830, Oak Ridge, Tennessee, USA

    C. Brihaye, T. A. Butler & F. F. Knapp Jr.

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  1. C. Brihaye
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  2. T. A. Butler
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Additional information

Research sponsored by the Office of Health and Environmental Research, U.S. Department of Energy under contract DE-AC05-840R21400 with Martin Marietta Energy Systems, Inc.

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Brihaye, C., Butler, T.A. & Knapp, F.F. The191Os/191mIr generator for clinical use. Journal of Radioanalytical and Nuclear Chemistry, Articles 102, 399–411 (1986). https://doi.org/10.1007/BF02047914

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  • DOI: https://doi.org/10.1007/BF02047914

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