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Journal of Radioanalytical and Nuclear Chemistry

, Volume 102, Issue 2, pp 309–320 | Cite as

Lipophilic technetium complexes

IV. Neutral, lipid-soluble technetium complexes with dithioligands containing Tc=O and Tc≡N cores. An in vitro study
  • S. Abram
  • U. Abram
  • H. Spies
  • R. Münze
Article

Abstract

A series of technetium complexes with different alkyl dithiocarbamates, dithiophosphates and xanthates has been prepared at tracer level (10−4 molar) starting from hydrazine-reduced pertechnetate and Tc(V) gluconate, respectively. Solution studies show the complexes to be neutral, lipid-soluble tracers. Their in vitro properties can be varied in a wide range by variation of alkyl substitution of the ligands.

Keywords

Physical Chemistry Inorganic Chemistry Gluconate Technetium Xanthate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    U ABRAM, H. SPIES, W. GÖRNER, R. KIRMSE, J. STACH, Inorg. Chim. Acta, 109 (1985) L9.Google Scholar
  2. 2.
    W. H. OLDENDORF, J. Nucl. Med., 19 (1978) 1182.Google Scholar
  3. 3.
    M. D. LOBERG, E. H. CORDER, A. T. FIELDS, P. S. CALLERY, J. Nucl. Med., 20 (1979) 1181.PubMedGoogle Scholar
  4. 4.
    A. YOKOYAMA, A. YAMADA, Y. ARANO, K. HORIUCHI, K. YAMAMOTO, K. TORIZUKA, Proc. 1st Intern. Symp. on Technetium in Chemistry and Nuclear Medicine, Padua 1982, p. 109.Google Scholar
  5. 5.
    H. F. KUNG, M. MOLNAR, J. BILLINGS, R. WICKS, M. BLAU, J. Nucl. Med., 25 (1984) 339.Google Scholar
  6. 6.
    H. SPIES, H. J. PIETZSCH, U. ABRAM, J. Radioanal. Nucl. Chem. Letters, 85 (1984) 339.Google Scholar
  7. 7.
    D. E. TROUTNER, W. A. VOLKERT, T. J. HOFFMAN, R. A. HOLMES, Intern. J. Appl. Radiation Isotopes, 35 (1984) 467.Google Scholar
  8. 8.
    W. A. VOLKERT, T. J. HOFFMAN, R. M. SEGER, D. E. TROUTNER, R. A. HOLMES, Eur. J. Nucl. Med., 9 (1984) 511.PubMedGoogle Scholar
  9. 9.
    S. HOLM, A. R. ANDERSEN, S. VORSTRUP, N. A. LASSEN, O. B. PAULSEN, R. A. HOLMES, J. Nucl. Med., 26 (1985) 1129.PubMedGoogle Scholar
  10. 10.
    S. JURISSON, E. SCHLEMPER, D. TROUTNER, L. CANNING, D. P. NOVOTNIK, J. Nucl. Med. All. Sci., 29 (1985) 201.Google Scholar
  11. 11.
    G. NECHVATAL, L. R. CANNING, S. A. CUMMING, D. P. NOVOTNIK, R. D. PICKETT, B. HIGLEY, R. D. NEIRINKX, W. A. VOLKERT, R. A. HOLMES, J. Nucl. Med. All. Sci., 29 (1985) 208.Google Scholar
  12. 12.
    D. P. NOVOTNIK, L. R. CANNING, S. A. CUMMING, G. NECHVATAL, I. M. PIPER, R. D. PICKETT, R. D. NEIRINKX, P. J. ELL, W. A. VOLKERT, R. A. HOLMES, J. Nucl. Med. All. Sci., 29 (1985) 209.Google Scholar
  13. 13.
    D. P. NOVOTNIK, L. R. CANNING, S. A. CUMMING, R. C. HARRISON, B. HIGLEY, G. NECHVATAL, R. D. PICKETT, I. M. PIPER, V. J. BAYNE, A. M. FORSTER, P. S. WEISNER, R. D. NEIRINKX, W. A. VOLKERT, D. E. TROUTNER, R. A. HOLMES, Nucl. Med. Comm., 6 (1985) 499.Google Scholar
  14. 14.
    H. F. KUNG, F. BLAU, J. Nucl. Med. 21 (1980) 147.PubMedGoogle Scholar
  15. 15.
    H. F. KUNG, F. BLAU, J. Med. Chem., 23 (1980) 1127.PubMedGoogle Scholar
  16. 16.
    H. S. WINCHELL, R. M. BALDWIN, T. H. LIN, J. Nucl. Med., 21 (1980) 940.PubMedGoogle Scholar
  17. 17.
    H. F. KUNG, K. M. TRAMPOSCH, M. BLAU, J. Nucl. Med., 24 (1983) 66.PubMedGoogle Scholar
  18. 18.
    K. M. TRAMPOSCH, H. F. KUNG, M. BLAU, J. Med. Chem., 26 (1983) 121.PubMedGoogle Scholar
  19. 19.
    T. H. LIN, B. M. WAR, J. L. WU, J. Nucl. Med., 25 (1984) 122.Google Scholar
  20. 20.
    L. A. EPPS, H. D. BURN, S. Z. LEVER, H. W. GOLDFARB, T. M. KERVITSKY, D. F. WONG, A. V. KRAMER, H. N. WAGNER, J. Nucl. Med. All. Sci., 29 (1985) 196.Google Scholar
  21. 21.
    S. Z. LEVER, H. D. BURN, T. M. KERVITSKY, W. H. GOLDFARB, D. W. WOO, D. F. WONG, L. A. EPPS, A. V. KRAMER, H. N. WAGNER, J. Nucl. Med., 26 (1985) 1287.PubMedGoogle Scholar
  22. 22.
    J. BALDAS, J. BONNYMAN, Intern. J. Appl. Radiation Isotopes, 36 (1985) 133.Google Scholar
  23. 23.
    U. ABRAM, H. SPIES, Inorg. Chim. Acta, 94 (1984) L3.Google Scholar
  24. 24.
    B. JOHANNSEN, H. SPIES, Chemistry and Radiopharmacology of Technetium Compounds (in German), Rossendorf, 1981.Google Scholar
  25. 25.
    J. BALDAS, J. BONNYMAN, P. M. POJER, G. A. WILLIAMS, M. F. MACKAY, J. Chem. Soc. Dalton Trans., (1981) 1798.Google Scholar
  26. 26.
    B. JOHANNSEN, Intern. J. Appl. Radiation Isotopes, 33 (1982) 429.Google Scholar
  27. 27.
    B. JOHANNSEN, R. BERGER, K. SCHOMÄCKER, Radiochem. Radioanal. Letters, 42 (1980) 177.Google Scholar
  28. 28.
    L. KADEN, B. LORENZ, K. SCHMIDT, H. SPRINZ, M. WAHREN, Isotopenpraxis, 17 (1981) 175.Google Scholar
  29. 29.
    J. BALDAS, J. BONNYMAN, P. M. POJER, G. A. WILLIAMS, Eur. J. Nucl. Med., 7 (1982) 187.PubMedGoogle Scholar
  30. 30.
    H. SPIES, B. JOHANNSEN, Inorg. Chim. Acta, 33 (1979) L113.Google Scholar
  31. 31.
    H. SPIES, B. JOHANNSEN, Inorg. Chim. Acta, 48 (1981) 255.Google Scholar
  32. 32.
    J. BALDAS, J. BONNYMAN, J. Nucl. Med. All. Sci., 29 (1985) 187.Google Scholar
  33. 33.
    S. ABRAM, U. ABRAM, H. SPIES, R. MÜNZE, Intern. J. Appl. Radiation Isotopes, 36 (1985) 653.Google Scholar
  34. 34.
    H. S. TROP, Ph. D. Thesis, Massachusetts Intstitute of Technology, 1979, cited in: A. DAVISON, A. G. JONES, Intern. J. Appl. Radiation Isotopes, 33 (1982) 875.Google Scholar
  35. 35.
    G. BANDOLI, M. NICOLINI, U. MAZZI, F. REFOSCO, J. Chem. Soc. Dalton Trans., (1984) 2505.Google Scholar

Copyright information

© Akadémiai Kiadó 1986

Authors and Affiliations

  • S. Abram
    • 1
  • U. Abram
    • 1
  • H. Spies
    • 1
  • R. Münze
    • 1
  1. 1.Central Institute of Nuclear Research RossendorfAcademy of Sciences of the G.D.R.Dresden, PF 19GDR

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