Acta diabetologia latina

, Volume 18, Issue 3, pp 259–266 | Cite as

Effect of indomethacin on the metabolic and hormonal response to a standardized breakfast in normal subjects

  • Alfred S. Luyckx
  • Daniel Guerten
  • André Scheen
  • Jean-Pierre Delporte
  • Pierre J. Lefebvre
  • François Jaminet
Original Contributions


We have investigated the influence of a single oral administration of indomethacin on blood glucose, plasma free fatty acids (FFA), α-amino-nitrogen, insulin and glucagon concentrations in young healthy subjects. Two groups of 6 subjects were studied, the first received a standardized 500 kcal mixed meal without any previous drug administration (controls) whereas the second group received 50 mg indomethacin 2 h before ingesting an identical meal. Plasma indomethacin concentration reached its maximum (2.36±0.36 Μg/ml) 15 min after administration and declined to 0.45±0.04 ug/ml after 2 h. Indomethacin ingestion was followed by a significant increase in blood glucose and plasma FFA reaching their maximum value at 45 min and returning to basal levels at 120 min. No simultaneous changes in plasma α-amino-nitrogen, insulin or glucagon levels were detected during this period. The meal was followed by a rise in blood glucose and plasma insulin as well as by a decrease in plasma FFA concentration. No significant differences were detected between the controls and the subjects receiving indomethacin. In controls, the meal was followed by a rise in plasma α-amino-nitrogen and a modest although significant increase in glucagon levels. In indomethacin-treated subjects, the increment of α-amino-nitrogen was less marked and the increase in plasma glucagon was not observed. Thus, indomethacin by itself can exert several metabolic effects; however, it does not deteriorate the blood glucose or insulin profile after a regular meal. The present work is the first to demonstrate that an inhibitor of prostaglandin synthesis inhibits the plasma glucagon rise occurring after a physiological stimulus such as a normal meal. On the basis of previousin vitro experiments, we suggest that this effect results from an inhibition of glucagon secretion by the PG synthesis inhibitor.


Free fatty acids Glucagon Indomethacin Insulin Meal tolerance test Normal subjects Prostaglandins 


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Copyright information

© Casa Editrice 1981

Authors and Affiliations

  • Alfred S. Luyckx
    • 1
  • Daniel Guerten
    • 1
  • André Scheen
    • 1
  • Jean-Pierre Delporte
    • 1
  • Pierre J. Lefebvre
    • 1
  • François Jaminet
    • 1
  1. 1.Secteur de Pharmacologie Clinique Secteur de Diabetologie Laboratoire de Pharmacie GaléniqueUniversité de LiègeBelgium

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