Acta diabetologia latina

, Volume 18, Issue 3, pp 259–266 | Cite as

Effect of indomethacin on the metabolic and hormonal response to a standardized breakfast in normal subjects

  • Alfred S. Luyckx
  • Daniel Guerten
  • André Scheen
  • Jean-Pierre Delporte
  • Pierre J. Lefebvre
  • François Jaminet
Original Contributions

Summary

We have investigated the influence of a single oral administration of indomethacin on blood glucose, plasma free fatty acids (FFA), α-amino-nitrogen, insulin and glucagon concentrations in young healthy subjects. Two groups of 6 subjects were studied, the first received a standardized 500 kcal mixed meal without any previous drug administration (controls) whereas the second group received 50 mg indomethacin 2 h before ingesting an identical meal. Plasma indomethacin concentration reached its maximum (2.36±0.36 Μg/ml) 15 min after administration and declined to 0.45±0.04 ug/ml after 2 h. Indomethacin ingestion was followed by a significant increase in blood glucose and plasma FFA reaching their maximum value at 45 min and returning to basal levels at 120 min. No simultaneous changes in plasma α-amino-nitrogen, insulin or glucagon levels were detected during this period. The meal was followed by a rise in blood glucose and plasma insulin as well as by a decrease in plasma FFA concentration. No significant differences were detected between the controls and the subjects receiving indomethacin. In controls, the meal was followed by a rise in plasma α-amino-nitrogen and a modest although significant increase in glucagon levels. In indomethacin-treated subjects, the increment of α-amino-nitrogen was less marked and the increase in plasma glucagon was not observed. Thus, indomethacin by itself can exert several metabolic effects; however, it does not deteriorate the blood glucose or insulin profile after a regular meal. The present work is the first to demonstrate that an inhibitor of prostaglandin synthesis inhibits the plasma glucagon rise occurring after a physiological stimulus such as a normal meal. On the basis of previousin vitro experiments, we suggest that this effect results from an inhibition of glucagon secretion by the PG synthesis inhibitor.

Key-words

Free fatty acids Glucagon Indomethacin Insulin Meal tolerance test Normal subjects Prostaglandins 

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Copyright information

© Casa Editrice 1981

Authors and Affiliations

  • Alfred S. Luyckx
    • 1
  • Daniel Guerten
    • 1
  • André Scheen
    • 1
  • Jean-Pierre Delporte
    • 1
  • Pierre J. Lefebvre
    • 1
  • François Jaminet
    • 1
  1. 1.Secteur de Pharmacologie Clinique Secteur de Diabetologie Laboratoire de Pharmacie GaléniqueUniversité de LiègeBelgium

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