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Metallobiochemistry of current environmental levels of trace metals: A new method of cyclotron production of48V for toxicological studies

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Abstract

No-carrier-added48V at 37 Mbq (mCi) levels was produced at the JRC-Ispra cyclotron by (α, n) reactions on a scandium target and used to label environmental and physiological levels of vanadium for metallobiochemical investigations. The radiochemical separation of48V from Sc is very simple and rapid and involves a single chromatographic step after fast dissolution of the bombarded target. The yield of the separation and the radioisotopic purity of the separated48V were nearly 100% A summary of the main results concerning different metabolic investigations on rats including absorption, retention, transfer of48V from mothers to newborns, binding with enzymes as well as uptake by cell culture system is reported.

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Authors and Affiliations

  1. Commision of the European Communities, Radiochemistry, Joint Research Centre, Ispra Establishment, 21020, Ispra (Va), (Italy)

    E. Sabbioni & G. Tanet

  2. Functional Materials Division, Joint Research Centre, Ispra Establishment, 21020, Ispra (Va), (Italy)

    B. Weckermann & M. Castiglioni

  3. Instituto Nazionale di Fisica Nucleare, University of Milan, Milan, (Italy)

    M. Bonardi

  4. Institute of Atomic Energy, Academy Science, Beijing, (China)

    Li Da-Kang

  5. CNR, Centre for Radiochemistry and Activation Analysis, University of Pavia, (Italy)

    M. Gallorini

Authors
  1. E. Sabbioni
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  2. M. Bonardi
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  3. G. Tanet
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  4. Li Da-Kang
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  5. M. Gallorini
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  6. B. Weckermann
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  7. M. Castiglioni
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Additional information

At the time of this study visiting scientists at the4,5Radiochemistry and3Functional Materials Divisions of the JRC-Ispra.

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Sabbioni, E., Bonardi, M., Tanet, G. et al. Metallobiochemistry of current environmental levels of trace metals: A new method of cyclotron production of48V for toxicological studies. Journal of Radioanalytical and Nuclear Chemistry, Articles 134, 199–208 (1989). https://doi.org/10.1007/BF02047283

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  • DOI: https://doi.org/10.1007/BF02047283

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