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Serum gastrin values in patients with familial adenomatous polyposis

  • Original Contributions
  • Published:
Diseases of the Colon & Rectum

Abstract

PURPOSE: An evaluation of the importance of gastrin in the colorectal carcinogenesis in patients with familial adenomatous polyposis was conducted. METHODS: Blood samples from 168 family members of 26 families were investigated for circulating gastrin. Blood was drawn from 65 affected patients, 66 clinically unaffected first-degree relatives, and 37 spouses. RESULTS: We did not find any difference in distribution of serum gastrin among these groups. CONCLUSION: Our results seem to exclude gastrin from being relevant in early carcinogenesis in patients with familial adenomatous polyposis.

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Authors and Affiliations

  1. Department of Surgical Gastroenterology C, Rigshospitalet, Blegdamsvej 9, DK-2100, Copenhagen Ø, Denmark

    Lars Bo Svendsen M.D., Jens Gustafsen M.D. & Flemming Stadil M.D.

  2. Department of Surgical Gastroenterology, Hvidovre Hospital, Denmark

    Steffen Bülow M.D.

  3. Institute of Human Genetics, University of Copenhagen, Copenhagen, Denmark

    Marie Luise Bisgård M.D.

Authors
  1. Lars Bo Svendsen M.D.
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  2. Marie Luise Bisgård M.D.
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  3. Jens Gustafsen M.D.
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  4. Steffen Bülow M.D.
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  5. Flemming Stadil M.D.
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Svendsen, L.B., Bisgård, M.L., Gustafsen, J. et al. Serum gastrin values in patients with familial adenomatous polyposis. Dis Colon Rectum 37, 22–25 (1994). https://doi.org/10.1007/BF02047209

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