Antonie van Leeuwenhoek

, Volume 30, Issue 1, pp 113–120 | Cite as

Antimicrobial activity of trialkylgermanium acetates and the influence of the medium

  • Antje Kaars Sijpesteijn
  • F. Rijkens
  • G. J. M. van der Kerk
  • A. Manten
Article

Abstract

A continued study of the antimicrobial activity of a series of trialkylgermanium acetates has confirmed earlier findings that the most active compounds against fungi are the ethyl and propyl derivatives, whereas for optimum antibacterial activity the chain length has to be somewhat greater. All fungi but only a few of the bacteria tested appear to be sensitive.

Incorporation of blood in the medium abolishes antibacterial activity but leaves antifungal activity unaltered.

Keywords

Acetate Ethyl Antimicrobial Activity Antibacterial Activity Chain Length 

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References

  1. Kaars Sijpesteijn, A., Rijkens, F., Luijten, J. G. A. andWillemsens, L. C. 1962. On the antifungal and antibacterial activity of some trisubstituted organogermanium, organotin and organolead compounds. Antonie van Leeuwenhoek28: 346–356.PubMedGoogle Scholar
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  4. Manten, A., Klöpping, H. L. andvan der Kerk, G. J. M. 1950. Investigations on organic fungicides. II. A new method for evaluating antifungal substances in the laboratory. Antonie van Leeuwenhoek16: 282–294.PubMedGoogle Scholar
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Copyright information

© Swets & Zeitlinger 1964

Authors and Affiliations

  • Antje Kaars Sijpesteijn
    • 1
  • F. Rijkens
    • 1
  • G. J. M. van der Kerk
    • 1
  • A. Manten
    • 2
  1. 1.Institute for Organic Chemistry T.N.O.UtrechtThe Netherlands
  2. 2.National Institute of Public HealthUtrechtThe Netherlands

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