Spironolactone-induced proliferation of smooth-surfaced endoplasmic reticulum in the liver of rats

  • K. Kovács
  • J. A. Blascheck
  • C. Gardell


Electron microscopic studies revealed that spironolactone, given orally to rats, causes a marked proliferation of smooth-surfaced endoplasmic reticulum in hepatocytes. The characteristic fine structural alterations in the liver may represent the morphologic equivalent of stimulation or induction of drug metabolizing microsomal enzymes and may explain why spironolactone protects rats against the injurious effects of different compounds.


Spironolactone Steroids, catatoxic Microsomal enzymes Hepatic endoplasmic reticulum Endoplasmic reticulum, hepatic 


Elektronenmikroskopische Untersuchungen zeigten bei der Ratte nach oral verabreichtem Spironolacton in den Hepatocyten eine starke Wucherung der glatten Oberflächen des endoplasmischen Reticulum. Die charakteristischen, feinen Strukturveränderungen in der Leber stellen möglicherweise das morphologische äquivalent einer Stimulierung oder Bildung von Enzymen dar, die körperfremde Stoffe metabolisieren. Damit ließe sich erklären, warum Spironolacton die Ratte gegen schädigende Einwirkungen verschiedener Substanzen zu schützen vermag.


Spironolacton Steroide, katatoxische Enzyme, mikrosomale Mikrosomale Enzyme Hepato-endoplasmisches Reticulum 


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Copyright information

© Springer-Verlag 1970

Authors and Affiliations

  • K. Kovács
    • 1
  • J. A. Blascheck
    • 1
  • C. Gardell
    • 1
  1. 1.Institut de Médecine et de Chirurgie expérimentalesUniversité de MontréalMontréalCanada

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