Summary
The influence of glucose on the release of free fatty acids (FFA) and glycerol has been studied in human subcutaneous adipose tissue in vitro. Increasing concentrations of glucose in the incubation medium exhibit an increased inhibition of the release of FFA. With concentrations of glucose over 2.5 mg per ml the release of glycerol is also inhibited; however, with lower concentrations glycerol release is stimulated. This suggests that glucose in physiological concentrations does not only influence the intracellular feed-back inhibition of lipolysis by increasing the rate of re-esterification of FFA, but also stimulates lipolysis by still unknown mechanisms.
Zusammenfassung
Am subcutanen menschlichen Fettgewebe wurde der Einfluß von Glucose auf die Lipolyse in vitro untersucht. Durch steigende Glucosekonzentrationen im Inkubationsmedium wird die Freisetzung von FFS zunehmend gebremst. Die Glycerinfreisetzung wird bei Glucosekonzentrationen über 2,5 mg/ml gleichfalls gehemmt, dagegen bei niedrigeren Glucosekonzentrationen stimuliert. Es ist anzunehmen, daß Glucose in physiologischen Konzentrationen nicht nur die intracelluläre Eigenhemmung der Lipolyse über die Rückveresterung von FFS beeinflußt, sondern auf noch nicht bekannte Weise die Lipolyse direkt stimuliert.
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Die Untersuchungen wurden mit Unterstützung des Landesamtes für Forschung des Landes Nordrhein-Westfalen durchgeführt.
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Thamer, G., Preiss, H., Gries, F.A. et al. Zum Einfluß der Glucose auf die Lipidmobilisation aus subcutanem menschlichem Fettgewebe in vitro. Z. Gesamte Exp. Med. 150, 94–100 (1969). https://doi.org/10.1007/BF02045843
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DOI: https://doi.org/10.1007/BF02045843