Skip to main content
SpringerLink
Log in

Eigenschaften heterologer Immunseren gegen Hundelymphocyten

  • Zürcher Transplantationskolloquium vom 25. bis 26. November 1966
  • Published:
Zeitschrift für die gesamte experimentelle Medizin einschließlich experimentelle Chirurgie

Zusammenfassung

Das Pferd ist für die Herstellung heterologer Immunseren gegen Lymphocyten besonders geeignet. Ein hoher Antikörpergehalt kann bei Immunisierung über 8–12 Wochen erreicht werden. Trotz hohen Reinheitsgrades des verwendeten Immunisierungsmaterials besitzt das Serum keine Zellspezifität gegen Lymphocyten. Ein Teil der unspezifischen Antikörperwirkungen kann in vitro absorbiert werden.

Summary

The horse is a suitable animal for producing heterologous antilymphocyte sera. By immunizing over 8–12 weeks a high antibody titer can be obtained. In spite of high purity of the immunizing antigen, the immunserum is not cell-specific. Some of the unspecific antibody effects can be absorbed in vitro.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Literatur

  1. Abaza, H. N., B. Nolan, J. G. Watt, andM. F. Woodruff: Effect of antilymphocytic serum on the survival of renal homotransplants in dogs. Transplantation5, 618 (1966).

    Article  Google Scholar 

  2. Gray, J. G., A. P. Monaco, M. L. Wood, andP. S. Russell: Studies on heterologous anti-lymphocyte serum in mice. I. In vitro and in vivo properties. J. Immunol.96, 217 (1966).

    PubMed  CAS  Google Scholar 

  3. Medawar, P. B.: persönliche Mitteilung.

  4. Monaco, A. P., W. M. Abott, H. B. Ottersen, R. L. Simons, M. L. Wood, M. H. Flax, andP. S. Russell: Antiserum to lymphocytes: Prolonged survival of canine renal homografts. Science153, 1264 (1966).

    Article  PubMed  CAS  Google Scholar 

  5. Pichlmayr, R.: Herstellung und Wirkung heterologer Antihundelymphocytenseren. Habil.-Schrift, München 1966. - Z. ges. exp. Med.143, 161 (1967).

    Article  CAS  Google Scholar 

  6. —,W. Brendel, G. Beck, E. Schmittdiel, G. Tidow u.I. Pichlmayr: Herstellung heterologer Immunseren gegen Lymphocyten des Hundes. Klin. Wschr.45, 199 (1967).

    Article  PubMed  CAS  Google Scholar 

  7. — —, u.I. Pichlmayr: Die immunsuppressive Wirkung eines heterologen Antihundelymphocytenserums. Z. ges. exp. Med.143, 313 (1967).

    Article  CAS  Google Scholar 

  8. Sacks, J. H., D. R. Fillipone, andD. M. Hume: Studies of immunodestruction of lymphoid tissue. Transplantation2, 60 (1964).

    Article  PubMed  CAS  Google Scholar 

  9. Starzl, T. E., T. L. Marchioro, T. D. Faris, R. J. McCardle, andY. Iwaski: Avenues of future research in homotransplantation of the liver. Amer. J. Surg.112, 391 (1966).

    Article  PubMed  CAS  Google Scholar 

  10. Waksman, B. H., S. Arbouys, andB. G. Arnason: Use of specific “lymphocyte” antisera to inhibit hypersensitve reactions reactions of “delayed” type. J. exp. Med.114, 997 (1961).

    Article  PubMed  CAS  Google Scholar 

  11. Woodruff, M. F. A.: Transplantation of tissues and organs, p. 100. Springfield (Ill.): Thomas 1960.

    Google Scholar 

  12. — andN. F. Anderson: The effect of lymphocyte depletion by thoracic duct fistula and administration of antilymphocytic serum on the survival of skin homografts in rats. Ann. N. Y. Acad. Sci.120, 119 (1964).

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Chirurgische Universitätsklinik München, Deutschland

    R. Pichlmayr, W. Brendel & G. Tidow

  2. Abteilung für experimentelle Chirurgie, Deutschland

    R. Pichlmayr, W. Brendel & G. Tidow

Authors
  1. R. Pichlmayr
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. W. Brendel
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. G. Tidow
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Die Untersuchungen wurden von der Deutschen Forschungsgemeinschaft unterstützt.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Pichlmayr, R., Brendel, W. & Tidow, G. Eigenschaften heterologer Immunseren gegen Hundelymphocyten. Z. Gesamte Exp. Med. 143, 299–305 (1967). https://doi.org/10.1007/BF02044985

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02044985

Search

Navigation