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Differential enzymatic behaviour of single proximal segments of the superficial and juxtamedullary nephron

I. Alkaline phosphatase, (Mg++) ATPase and (Na+K+) ATPase

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Zeitschrift für die gesamte experimentelle Medizin einschließlich experimentelle Chirurgie

Summary

With three phosphohydrolases, i. e. alkaline phosphatase (Na+K+), ATPase and (Mg++) ATPase, a segmentation of the proximal tubule and a marked difference between the short (superficial) and long (Juxtamedullary) nephron is revealed by quantitative histochemistry. With the exception of the superficial nephron of the male rat, alkaline phosphatase activity increases along the proximal tubule independent of sex. (Na+K+) ATPase and (Mg++) ATPase show in both types of nephrons a decrease of activity along the proximal tubule. The juxtamedullary nephron is more active than the superficial. Parallelism of the site of avtivity for alkaline phosphatase and the location of reabsorption of phosphate ions is discussed. Morphological and physiological data from the literature are brought into connexion with the enzymatic changes of a (Na+K+) ATPase activity decrease.

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Authors and Affiliations

  1. Enzyme Laboratory, Medical Policlinic of the University of Basle, Switzerland

    U. Schmidt & U. C. Dubach

  2. Institute of Pathology, University of Tuebingen, Germany

    U. Schmidt & U. C. Dubach

Authors
  1. U. Schmidt
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  2. U. C. Dubach
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Additional information

Supported by grant Nr. 4809 of the “Schweiz. Nationalfonds zur Förderung der wissenschaftlichen Forschung”.

With the technical assistance of Mrs. I. Bieder and Miss M. Kirstein.

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Schmidt, U., Dubach, U.C. Differential enzymatic behaviour of single proximal segments of the superficial and juxtamedullary nephron. Z. Gesamte Exp. Med. 151, 93–102 (1969). https://doi.org/10.1007/BF02044665

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  • DOI: https://doi.org/10.1007/BF02044665

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