Lactase activity in experimental rickets and vitamin D intoxication

  • A. Berio
  • A. Vogel
  • G. M. Lamedica
  • S. Nordio
Kurze Mitteilung

Summary

In rats intoxicated with vitamin D intestinal lactase activity was significantly decreased. In contrast, rachitic animals showed rather high values of this disaccharidase. In rachitic rats treated with vitamin D lactase levels were found to be intermediate between rachitic animals and controls.

Key-words

Rickets Lactase Vitamin D Calcium metabolism 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literature

  1. 1.
    Au, W. Y. W., andL. G. Raisz: Restoration of parathyreoid responsiveness in vitamin D deficient rats by parenteral calcium or dietary lactose. J. clin. Invest.46, 1572–1578 (1967).PubMedGoogle Scholar
  2. 2.
    Auricchio, S., A. Rubino, R. Tosi, G. Semenza, M. Landolt, H. J. Kister, andA. Prader: Disaccharidase activities in human intestinal mucosa. Enzym. biol. clin.3, 193–208 (1963).Google Scholar
  3. 3.
    Dupuis, Y., etP. Fournier: Effects antirachitiques comparés du lactose et de la vitamine D, seuls ou associés. Compt. Rend. Soc. Biol.159, 576–579 (1965).Google Scholar
  4. 4.
    Nordio, S., A. Berio, R. Gatti, andG. M. Lamedica: Relationships between lactase activity and calcium absorption. Lactose intolerance in hyperparathyreoidism. Ann. paediat. (Basel)206, 85–96 (1966).Google Scholar
  5. 5.
    —,E. Bertolotti, eR. Gatti: Due casi con alterazioni non comuni del ricambio calcio-fosforico. Disparatiroidismo (ipo-iperparatiroidismo?) Difetto di concentrazione delle urine secondario ad ipercalcemia idiopatica. Minerva pediat.17, 79–86 (1965).PubMedGoogle Scholar
  6. 6.
    —,G. Lamedica, L. Vignolo, andA. Berio: Six cases of lactose intolerance. Lactose intolerance and coeliac disease. Disaccharidase activity in the intestinal mucosa ascertained with the peroral biopsy. Ann. paediat. (Basel)204, 3–23 (1965).Google Scholar
  7. 7.
    —, eR. Gatti: Moderni orientamenti sul transporto organico del calcio. L'ipercalciuria idiopatica del bambino. Rev. esp. Pediat.23, 549 (1967).Google Scholar
  8. 8.
    — —, eM. Tambussi: Il nanismo ipercalciurico. Minerva pediat.18, 1221–1227 (1966).PubMedGoogle Scholar
  9. 9.
    —,G. M. Lamedica, A. Berio, andR. Gatti: Lactase deficiency in de Toni-Debré-Fanconi Syndrome. Relationships between lactase activity and calcium absorption. Ann. paediat. (Basel)206, 165–174 (1966).Google Scholar
  10. 10.
    — — —, andL. Vignolo: Disaccharidase activities of duodenal mucosa in children. Ann. paediat. (Basel)206, 297–312 (1966).Google Scholar
  11. 11.
    Yet-oy Chang, andD. M. Hegsted: Lactose and calcium transport in gut sac. Nutrition (Lond.)82, 297–300 (1964).Google Scholar

Copyright information

© Springer-Verlag 1968

Authors and Affiliations

  • A. Berio
    • 1
    • 2
  • A. Vogel
    • 1
    • 2
  • G. M. Lamedica
    • 1
    • 2
  • S. Nordio
    • 1
    • 2
  1. 1.Clinica Pediatrica G. GasliniGenova
  2. 2.Universitätskinderklinik WürzburgDeutschland

Personalised recommendations