Serotoninic headache from epidural dorsal cord stimulation. A case report that raises questions

  • Broggi G. 
  • Franzini A. 
  • Giovannini P. 
  • Crenna P. 
Case Reports


A case of chronic benign pain due to spondylarthrosis secondary to infantile poliomyelitis, in which dorsal cord stimulation (DCS) produced analgesia but precipitated severe migraine, is reported. 5-HIAA and HVA in CSF and the R III spinal reflexes were studied during D.C.S.

Since metergoline and later 5-OH-tryptophan were effective in blocking headache sparing the analgesia, the hypothetical mechanisms of D.C.S. analgesia are discussed.


Neurostimulation 5 HT Headache 


Si descrive un caso di dolore cronico “benigno” dovuto a spondilartrosi secondaria a poliomielite infantile. La stimolazione del midollo spinale (D.C.S.) ha indotto analgesia ma anche ha provocato, a distanza di tempo, una grave emicrania. Sono stati studiati i livelli di 5HIAA e HVA nel liquor cefalorachidiano ed i riflessi spinali RIII durante la D.C.S. La metergolina e poi il 5-OH-Triptofano hanno bloccato la cefalea, senza modificare l'analgesia. Su questi risultati ed osservazioni, si discutono i possibili meccanismi dell'analgesia indotta dalla D.C.S.


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Copyright information

© Masson Italia Periodici S.r.l. 1984

Authors and Affiliations

  • Broggi G. 
    • 1
  • Franzini A. 
    • 1
  • Giovannini P. 
    • 2
  • Crenna P. 
    • 3
  1. 1.Divisione Neurochirurgicadell'Istituto Neurologico “C. Besta”Milano
  2. 2.Divisione Neurologicadell'Istituto Neurologico “C. Besta”Milano
  3. 3.Divisione di Neurofisiologiadell'Istituto Neurologico “C. Besta”Milano

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