Summary
The changes in the Na/K ratio were followed on 24-hour samples of urine repeatedly taken at 7-day intervals during multiple X-irradiation of mice with single exposures of 200 r (up to a total exposure of 1200 r). The fluctuation of the Na/K ratio in the course of the experiments on the individual animals was analysed by using certain principles of time series statistics. Three characteristics were chosen, i.e. regularity of fluctuation, mean amplitude and level of fluctuation of the Na/K ratio. It was shown that low and high amplitudes of fluctuation, accompanied by fluctuation about low and high levels and the least regular type of fluctuation, constitute, from the viewpoint of radiosensitivity of the experimental animals, an unfavourable prognostic sign. The authors stress the importance of these findings for solving problems relating to differing individual sensitivity to radiation.
Zusammenfassung
Die Autoren verfolgten die Veränderungen im Na/K Verhältnis an 24stündigen Urinproben, die wiederholt in siebentägigen Intervallen während mehrfacher Röntgenbestrahlung von Mäusen mit Expositionen von 200 r (bis zu einer Gesamtbestrahlung von 1200 r) abgenommen wurden. Die Schwankungen im Na/K Verhältnis im Laufe der Experimente an den einzelnen Tieren wurden mittels gewisser Prinzipien der Zeitserienstatistik analysiert. Drei Charakteristiken wurden gewählt, nämlich die Regelmäßigkeit der Schwankungen, die Fluktuationsamplitude und das Fluktuationsniveau des Na/K-Verhältnisses. Es wurde gezeigt, daß hohe und niedrige Fluktuationsamplituden, begleitet von hohen und niedrigen Fluktuationsniveauwerten, und der am wenigsten regelmäßige Fluktuationstyp, vom Gesichtspunkt der Radiosensitivität des Versuchstieres, ein ungünstiges prognostisches Zeichen sind. Die Autoren betonen die Wichtigkeit dieser Feststellungen für die Lösung der sich auf die interindividuelle Differentiation der Radiosensitivität beziehenden Probleme.
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Pospíšil, M., Šikulová, J. & Ševčík, F. The fluctuation of urine electrolyte excretion and its relation to mortality of multiple irradiated mice. Z. Gesamte Exp. Med. 139, 112–121 (1965). https://doi.org/10.1007/BF02043929
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DOI: https://doi.org/10.1007/BF02043929