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Stroke in two young siblings with congenital dysfibrinogenemia

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Abstract

Two young siblings (a male of 21 and his sister of 26 years) suffered from arterial thrombosis episodes of the carotid and abdominal aorta documented by angiographic studies. In the absence of any known predisposing factor in the family and personal history, the laboratory investigation of both patients revealed coagulation abnormalities compatible with a dysfibrinogenemia. The occurrence of a similar defect also in plasma of one of the propositi's asymptomatic relatives is suggestive of an inherited fibrinogen disorder

Sommario

Un nuovo tipo di fibrinogeno abnorme è stato osservato in tre giovani fratelli calabresi nati da genitori consanguinei (cugini di 1° grado). Due di essi, hanno subito in giovane età un ictus cerebrale mentre il terzo fratello, è, in atto, clinicamente asintomatico.

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Authors and Affiliations

  1. Clinica Neurologica (R), I Facoltà di Medicina e Chirurgia, Università di Napoli, Italia

    Quattrone A., Colucci M., Donati M. B., Meduri M., Mussoni L., Roncaglioni M. C., Semeraro N., Carlomagno S. & Bonavita V.

  2. Laboratorio di Emostasi e Trombosi, Istituto di Ricerche Farmacologiche M. Negri, Milano

    Colucci M., Donati M. B., Roncaglioni M. C. & Semeraro N.

  3. Clinica Neurologica, Università di Messina, Italia

    Quattrone A. & Meduri M.

Authors
  1. Quattrone A.
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  2. Colucci M.
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  3. Donati M. B.
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  4. Meduri M.
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  5. Mussoni L.
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  6. Roncaglioni M. C.
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  7. Semeraro N.
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  8. Carlomagno S.
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  9. Bonavita V.
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Additional information

This work was supported by the Italian National Research Council (“Clinical Pharmacology and Rare Diseases”) and by a grant of the Mario Negri Foundation, New York, N.Y., USA.

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Quattrone, A., Colucci, M., Donati, M.B. et al. Stroke in two young siblings with congenital dysfibrinogenemia. Ital J Neuro Sci 4, 229–232 (1983). https://doi.org/10.1007/BF02043912

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  • DOI: https://doi.org/10.1007/BF02043912

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