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The role of MHC class I and class II molecules in susceptibility to Lyme disease in inbred B10 H-2 congenic and recombinant mice

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International Journal of Angiology

Abstract

We have further developed the mouse model of Lyme disease using B10 H-2 congenic and recombinant strains. The influence of MHC class I and class II genes of the mouse H-2 complex on the susceptibility and/or resistance to Lyme disease was studied. We report that B10 strains congenic to the haplotypes, H-2k, H-2d, H-2f, H-2q, and H-2b are highly susceptible to Lyme disease as they develop high antibody titers and severe disease over mice of other haplotypes used in this study. By using recombinant strains we demonstrate that this susceptibility is genetically based and specifically involves the K and D regions (MHC class I genes) and I-A and I-E regions (MHC class II genes) of the H-2 complex.

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Authors and Affiliations

  1. Department of Biology, Texas A&M University, College Station, Texas

    Sunitha Reddy M.S.

  2. Department of Veterinary Pathobiology, Texas A&M University, College Station, 77843, TX, USA

    Colin R. Young Ph.D. & Regina Hokanson B.S.

  3. Texas Department of Health, Austin, Texas

    Julie Rawlings MPH.

  4. Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA

    Chella S. David Ph.D.

Authors
  1. Sunitha Reddy M.S.
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  2. Colin R. Young Ph.D.
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  3. Regina Hokanson B.S.
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  4. Julie Rawlings MPH.
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  5. Chella S. David Ph.D.
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Reddy, S., Young, C.R., Hokanson, R. et al. The role of MHC class I and class II molecules in susceptibility to Lyme disease in inbred B10 H-2 congenic and recombinant mice. International Journal of Angiology 4, 88–93 (1995). https://doi.org/10.1007/BF02043624

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