The Italian Journal of Neurological Sciences

, Volume 3, Issue 4, pp 289–293 | Cite as

Brainstem auditory evoked potentials in the diagnosis of multiple sclerosis

  • Mantia L. La 
  • Milanese C. 
  • Corridori F. 
  • Brusa M. 
  • Formenti A. 
  • Cocchini F. 
  • Richichi M. 
Original Articles

Abstract

Brainstem auditory evoked potentials (BAEPs) have been investigated in 34 patients affected by Multiple Sclerosis. Abnormalities were found in 68% of the patients. Silent lesions of the brainstem were detected in 60% of the clinically definite and in 44% of the probable cases. The diagnostic value of these findings is discussed.

Key-words

Brainstem auditory evoked potentials multiple sclerosis 

Sommario

I potenziali evocati uditivi sono stati investigati in 34 pazienti affetti da sclerosi multipla. Anormalità sono state evidenziate nel 68% dei pazienti affetti da sclerosi multipla clinicamente definita. Lesioni silenti del brainstem sono state trovate nel 60% delle forme clinicamente definite e nel 44% di quelle probabili. Il valore diagnostico di questi reperti è discusso.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. [1]
    Brown F.R., Shimizu H., McDonald J.M., Moser A.B., Marquis P., Chen W.W., Moser H.W.Auditory evoked brainstem responses and high performance liquid chromatography sulfatide assay as early indices of metachromatic leukodystrophy. Neurology, 31; 980–985, 1981PubMedGoogle Scholar
  2. [2]
    Buchwald J.J., Huang C.M.Far-field acoustic response: origins in the cat. Science 189: 382–384, 1975PubMedGoogle Scholar
  3. [3]
    Chiappa K.H., Harrison J.L., Brooks E.B., Young R.R.Brainstem auditory evoked responses in 200 patients with multiple sclerosis. Ann. Neurol., 7: 135–143, 1980.CrossRefPubMedGoogle Scholar
  4. [4]
    Chiappa K.H.Pattern shift visual, brainstem auditory and short-latency somatosensory evoked potentials in multiple sclerosis. Neurology, 30: 110–123, 1981.Google Scholar
  5. [5]
    Chiappa K.H., Ropper A.H.Evoked potentials in clinical medicine. N. Engl. J. Med. 306: 1140–1150, 1982.PubMedCrossRefGoogle Scholar
  6. [6]
    Fujita M., Hosoki M., Miyazaki M.Brainstem auditory evoked responses in spinocerebellar degeneration and Wilson disease. Ann. Neurol. 9: 42–47, 1981.CrossRefPubMedGoogle Scholar
  7. [7]
    Karnase D.S., Marshall L.F., McCarthy C.S., Klauber M.R., Bickford R.G.Localizing and prognostic value of auditory evoked responses in coma after closed head injury. Neurology 32 (3) 299–302, 1982PubMedGoogle Scholar
  8. [8]
    Khoshbin S., Hallett M.Multimodality evoked potentials and blink reflex in multiple sclerosis. Neurology 31: 138–144, 1981PubMedGoogle Scholar
  9. [9]
    Kjaer M.Variations of brainstem auditoryevoked potentials correlated to duration and severity of multiple sclerosis. Acta Neurol. Scand. 61: 157–166, 1980.PubMedCrossRefGoogle Scholar
  10. [10]
    Lehtinen I., Frey H.Neurophvsiological diagnosis of multiple sclerosis. Acta Neurol. Scand. Suppl. 67, 57: 236–241, 1978Google Scholar
  11. [11]
    Lev A., Sohmer H.Sources of averaged neural responses recorded in animal and human subjects during cochlear audiometry. Arch. Klin. Exp. Ohr-Nas-Kehlkheilk 201: 79–90, 1972CrossRefGoogle Scholar
  12. [12]
    McDonald W.I., Halliday A.M.Diagnosis and classification of multiple sclerosis. Brit. Med. Bull. 33: 4–8, 1977PubMedGoogle Scholar
  13. [13]
    Maurer K., Schafer E., Hopf H.C., Leitne H.The location by early auditory evoked potentials of acoustic nerve and brainstem demyelination in multiple sclerosis. J. Neurol. 223: 45–58, 1980CrossRefGoogle Scholar
  14. [14]
    Ochs R., Markand O.N., De Myer W.E.Brainstem auditory evoked responses in leukodystrophies. Neurology 29: 1089–1093, 1979.PubMedGoogle Scholar
  15. [15]
    Parker S.W., Chiappa K.H., Brooks E.B.Brainstem auditory evoked responses in patients with acoustic neuromas and cerebellar-pontine angle meningiomas. Neurology 30: 413–414, 1980.Google Scholar
  16. [16]
    Parving A., Elberling G., Smith T.Auditory electrophysiology: findings in multiple sclerosis. Audiology, 20: 123–142, 1981PubMedGoogle Scholar
  17. [17]
    Picton T.W., Hillyard S.A., Krausz H.I., Galambos R.,Human Auditory evoked potentials: evaluation of components. Electroenc. Clin. Neurophysiol. 36: 179–190, 1974.CrossRefGoogle Scholar
  18. [18]
    Prasher D.K., Gibson W.P.R.Brainstem auditory evoked potentials: a comparative study of monoaural versus binaural stimulation in the detection of multiple sclerosis. Electroenceph. Clin. Neurophysiol., 50: 247–253, 1980.CrossRefPubMedGoogle Scholar
  19. [19]
    Robinson K., Rudge P.:Abnormalities of the auditory evoked potentials in patients with multiple sclerosis. Brain 100: 19–40, 1977.PubMedGoogle Scholar
  20. [20]
    Robinson K., Rudge P.:Tue use of the auditory evoked potential in the diagnosis of multiple sclerosis. J. Neurol. Sci. 45: 235–244, 1980.CrossRefPubMedGoogle Scholar
  21. [21]
    Shanon E., Gold S., Himmelfarb M.Z., Carasso R.Auditory potentials of cochlear nerve and brainstem in multiple sclerosis. Arch. Otolaryngol. 105: 505–508, 1979.PubMedGoogle Scholar
  22. [22]
    Starr A., Achor L.J.Auditory brainstem responses in neurological diseases. Arch. Neurol. 32: 761–768, 1975.PubMedGoogle Scholar
  23. [23]
    Starr A., Achor L.J.The generators of the auditory brainstem potentials as revealed by brainstem lesions in both cat and man. In: Evoked electrical activity in the auditory nervous system. Ed. R. Nanton and C. Fernandez Acad press NY 1978, 443–452.Google Scholar
  24. [24]
    Starr A.:Clinical relevance of brainstem auditory evoked potentials in brainstem disorders in man. In: Auditory Evoked Potential in Man. Psychophar. Correlates of evoked potentials. Progress in Clinic. Neurophysiol. Ed. J.E. Desmedt, Karger and Basel 1977, 2, 45–57.Google Scholar
  25. [25]
    Stockard J., Stockard J., Sharbrough F.W.Detection and localization of occult lesions with brainstem auditory responses. Mayo Clinic Proc. 52: 761–769, 1977.Google Scholar
  26. [26]
    Soudant J., Frochet B., Frochet M.M., Praloux P., Delaporte P., Salama J.Etude des potentiels évoqués auditifs au cours de la sclérose en plaquer. Rev. Neurol. 135: 895–901, 1979.Google Scholar
  27. [27]
    Trojaborg W., Bottcher J., Saxtrup O.Evoked potentials and immunoglobulin abnormalities in multiple sclerosis. Neurology 31: 866–871, 1981.PubMedGoogle Scholar

Copyright information

© Masson Italia Editori S.p.A. 1982

Authors and Affiliations

  • Mantia L. La 
    • 1
  • Milanese C. 
    • 1
  • Corridori F. 
    • 1
  • Brusa M. 
    • 2
  • Formenti A. 
    • 2
  • Cocchini F. 
    • 2
  • Richichi M. 
    • 2
  1. 1.Istituto Neurologico “C. Besta”Milano
  2. 2.Laboratorio di fisiopatologia del sistema uditivo Ospedale Fatebenefratelli-Istituto Neurologico “C. Besta”Milano

Personalised recommendations