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International Journal of Angiology

, Volume 5, Issue 1, pp 8–14 | Cite as

Effects of nilvadipine, a calcium antagonist, on intimal thickness of vascular grafting in cholesterol-fed rabbits

  • Koichi Yoshimura
  • Kensuke Esato
  • Kentaro Fujioka
Original Articles
  • 21 Downloads

Abstract

The effects of nilvadipine on intimal thickness in expanded poly-tetrafluoroethylene grafts were examined in 21 rabbits undergoing infrarenal aorta reconstruction. Seven rabbits received commercial rabbit chow (control group), seven, a regular diet supplemented with 1% cholesterol (cholesterol group); and seven, the cholesterol diet with 98.9% pure nilvadipine 1 mg/kg/day (nilvadipine group). Grafts were harvested 3 months after surgery for histologic examination. Intimal thickness at the proximal and distal anastomosis was, respectively, 225±76 and 273±110 m in the control group, 525±236 and 600±250 m in the cholesterol group, and 284±94 and 241±86 m in the nilvadipine group. Intimal thickness in the cholesterol group was significantly greater than in the nilvadipine group (p<0.01). The smooth muscle cell values in the intima at the proximal and distal anastomosis were, respectively, 10.6±3.6 and 12.6±3.2 %Extinction (%E) in the control group, 15.5±4.0 and 16.1±4.5 %E in the cholesterol group, and 9.1±3.1 and 9.6±2.1 %E in the nilvadipine group. The smooth muscle cell value in the intima of the cholesterol group was greater than that of the nilvadipine group (p<0.01). These data suggest that nilvadipine significantly reduces the degree of intimal thickness in expanded polytetrafluoroethylene grafts in cholesterol-fed rabbits, and that this effect is due to inhibition of smooth muscle cell migration and proliferation.

Keywords

Cholesterol Smooth Muscle Cell Calcium Antagonist Cholesterol Diet Vascular Grafting 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© International College of Angiology, Inc. 1996

Authors and Affiliations

  • Koichi Yoshimura
    • 1
  • Kensuke Esato
    • 1
  • Kentaro Fujioka
    • 1
  1. 1.First Department of SurgeryYamaguchi University School of MedicineYamaguchiJapan

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