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Creutzfeldt-Jakob disease in the province of Siena: Two cases transmitted to monkeys

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Abstract

Two cases of histopathologically documented Creutzfeldt-Jakob disease were observed in the same area of the province of Siena in 1974–1975. The transmission of the disease was obtained through brain homogenates and lymphnodes in one of the two cases.

This confirms that the agent is present in other tissues besides the brain and underlines further the analogies between Creutzfeldt-Jakob disease and scrapie.

Sommario

Due casi di Creutzfeldt-Jakob, documentati istopatologicamente, sono stati osservati in vicinanza cronologica e territoriale, in provincia di Siena nel 1974–1975.

La trasmissibilità della malattia è stata ottenuta sia da omogenati di cervello che da linfonodi, in uno dei due casi.

Questo conferma che l'agente è presente in altri tessuti oltre che nel cervello, e sottolinea ulteriormente le analogie tra Creutzfeldt-Jakob e Scrapie.

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References

  1. Alemá G.:Aspectos epidemiólogicos de la enfermedad de Jakob-Creutzfeldt. (Consideraciones sobre los casos italianos). In:de la Fuente R., Weisman, M.N. (eds.):Psychiatry. Proc. 5th World Cong. Psychiatry (International Congress Series No. 274). Amsterdam, Excerpta Medica, pp. 1221–1227, 1971

    Google Scholar 

  2. Asher D.M., Gibbs C.J. Jr.,Gajdusek D.C.:Pathogenesis of subacute encephalopathies. Ann. Clin. Lab. Sci. 6: 84–103, 1976.

    PubMed  Google Scholar 

  3. Bisanti L.:Una Review Epidemiologica della Creutzfeldt-Jakob Disease. Atti del 2° Convegno Nazionale di Neuroepidemiologia. Milano, 12–13 Dec. 1980, pp. 117–122.

  4. Brown P.:An epidemiologic critique of Creutzfeldt-Jakob disease. Epidemiologic Reviews, vol. 2, 113–135, 1980.

    PubMed  Google Scholar 

  5. Brown P., andCathala F.:Creutzfeldt-Jakob disease in France. III. Epidemiological study of 170 patients dying during the decade 1968–1977. Ann. Neurol. 6: 438–446, 1979.

    Article  PubMed  Google Scholar 

  6. Brown P., andCathala F.:Creutzfeldt-Jakob disease in France. In:Prusiner, S.B., Hadlow, W.J. (eds.):Slow Transmissible Diseases of the Nervous System. Academic Press, New York, Volume 1: 213–227, 1979.

    Google Scholar 

  7. Field E.J.:Scrapie: a review of its relation to human disease and ageing. J. Med. Genetics, 1976. 13: 479–494.

    Google Scholar 

  8. Galvez S., Masters C., andGajdusek D.C.:Descriptive epidemiology of Creutzfeldt-Jakob disease in Chile. Arch. Neurol. 37: 11–14, 1980.

    PubMed  Google Scholar 

  9. Gibbs C.J., Gajdusek D.C., Asher D.M., et al;:Creutzfeldt-Jakob disease (spongiform encephalopathy): transmission to the chimpanzee. Science 161: 388–389, 1968.

    PubMed  Google Scholar 

  10. Hadlow W.J., Race R.E., Kennedy R.C., Eklund CM.:Natural infection of sheep with scrapie virus. In:Prusiner, S.B., Hadlow W.J. (eds.):Slow Transmissible Diseases of the Nervous System. Academic Press, New York, Volume 2: 3–12, 1979.

    Google Scholar 

  11. Kahana E., Alter M., Braham J., et al:Creutzfeldt-Jakob disease: a focus among Libyan Jews in Israel. Science 183: 90–91, 1974.

    PubMed  Google Scholar 

  12. Lechi A.:Quoted by Masters et al., 1979.

    Article  PubMed  Google Scholar 

  13. Majtenyi C.:Creutzfeldt-Jakob disease in Hungary.J. Neuropathol. Exp. Neurol. 37: 653, 1978.

    Google Scholar 

  14. Masters C.L., Harris J.O., Gajdusek D.C., et al:Creutzfeldt-Jakob disease: patterns of worldwide occurrence and the significance of familial and sporadic clustering. Ann. Neurol. 5: 177–188, 1979.

    Article  PubMed  Google Scholar 

  15. Matthews W.B.:Epidemiology of Creutzfeldt-Jakob disease in England and Wales. J. Neurol. Neurosurg. Psychiatry 38: 210–213, 1975.

    PubMed  Google Scholar 

  16. Mayer V., Mitrova E., andOrolin D.,Creutzfeldt-Jakob disease in Czechoslovakia and a working concept of its surveillance. In:Prusiner,S.B., andHadlow,W.J. (eds.):Slow Transmissible Diseases of the Nervous System. Academic Press, New York, Volume 1: 287–304, 1979.

    Google Scholar 

  17. Tabaton M., Bugiani O., Mancardi G.L. et al.:Creutzfeldt-Jakob disease in the city and district of Genoa: estimated mortality rate in the six year period 1974–1979. Ital. J. Neurol. Sci; 2: 189–192, 1981.

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Clinica Neurologica, Università, Roma

    Fieschi C. & Orzi F.

  2. Clinica Neurologica, Università, Siena

    Nardini M. & Rocchi F.

  3. Laboratory of Central Nervous System Studies, National Institute of Neurological and Communicable Disorders and Stroke, National Institutes of Health, Bethesda, Maryland

    Pocchiari M., Asher D., Gibbs C. & Gajdusek D.

Authors
  1. Fieschi C.
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  2. Orzi F.
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  3. Pocchiari M.
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  4. Nardini M.
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  5. Rocchi F.
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  6. Asher D.
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  7. Gibbs C.
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  8. Gajdusek D.
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Fieschi, C., Orzi, F., Pocchiari, M. et al. Creutzfeldt-Jakob disease in the province of Siena: Two cases transmitted to monkeys. Ital J Neuro Sci 4, 61–64 (1983). https://doi.org/10.1007/BF02043438

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  • DOI: https://doi.org/10.1007/BF02043438

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