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The Italian Journal of Neurological Sciences

, Volume 3, Issue 3, pp 211–214 | Cite as

Electrophysiological measures (CNV — EEG) and Nitrous Oxide at low doses in man

  • Pozzessere G. 
  • Pierelli F. 
  • Rizzo P. A. 
  • Gerono A. 
  • Niethammer T. 
  • Morocutti C. 
  • Timsit-Berthier M. 
Original Articles
  • 37 Downloads

Abstract

Nitrous oxide(N2O) is a widely used inhalational anesthetic gas, but its exact mode of action and its distribution in the CNS are not yet well known. The aim of this research was to study the effects of N2O at low doses (10 percent) in the CNS of humans.

Five healthy volunteers were tested. Contingent Negative Variation (CNV), Reaction time (RT) and quantified EEG recordings were taken while subjects were breathing air and thenN2O. A significant reduction of the postimperative positive CNV components during N2O inhalation was observed;no changes in EEG power spectrum and RT values were seen. These results could be consistent with an earlyN2O interference with processes underlying CNV resolution, while vigilance and attention were still maintained.

Key-words

Nitrous oxide contingent negative variation reaction time EEG power spectrum measures 

Sommario

Il protossido di azoto(N2O) è un gas anestetico largamente utilizzato, ma non è ancora ben conosciuto il suo modo di azione né la sua distribuzione nel SNC.

Scopo di questa ricerca è stato quello di valutare gli effetti di tale gas a basse dosi (10 per cento) sul SNC nell'uomo.

Sono state condotte registrazioni dell'onda di aspettativa (CNV) del tempo di reazione e dello spettro di potenza dell'EEG in cinque soggetti sani volontari, mentre questi respiravano aria e poi mentre respiravanoN2O al 10 per cento.

È stata riscontrata una significativa riduzione dei parametri positivi post-imperativi della CNV durante l'uso diN2O mentre non venivano osservate variazioni dello spettro di potenza e del tempo di reazione.

Tali risultati potrebbero essere attribuiti ad una precoce interferenza dell'N2O sui processi che sottendono la risoluzione della CNV, anche quando sono ancora integre la vigilanza e l'attenzione.

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Copyright information

© Masson Italia Editori S.p.A. 1982

Authors and Affiliations

  • Pozzessere G. 
    • 1
  • Pierelli F. 
    • 1
  • Rizzo P. A. 
    • 1
  • Gerono A. 
    • 2
  • Niethammer T. 
    • 2
  • Morocutti C. 
    • 3
  • Timsit-Berthier M. 
    • 2
  1. 1.Istituto di II Clinica NeurologicaUniversità di RomaItaly
  2. 2.Laboratoire de Neurophysiologie clinique et de Psychopathologie Université de LiègeBelgium
  3. 3.IV Cattedra di Clinica NeurologicaUniversità di RomaItaly

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