Abstract
A baby with infantile spasms (West's syndrome) who developed acute-onset transient hydrocephalus 10 days after suspending ACTH treatment is described. Hydrocephalus is an unusual complication of A CTH therapy, the more common complication being benign intracranial hypertension. The probable common pathogenic mechanism of altered CSF reabsorption which may lead to the two different clinical states, depending on age of patient, is discussed.
Sommario
Vierte descritto un lattante affetto da S. di West che ha manifestato idrocefalo ad insorgenza acuta, dopo spspensione di ACTH.
È noto che l'ACTH può essere causa di ipertensione intracranica benigna piuttosto che di idrocefalo. Viene discusso il probabile comune meccanismo patogenetico legato ad un alterato riassorbimento del liquido cefalorachidiano, che condurrebbe ai due diversi quadri clinici in rapporto alla età del paziente.
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Laverda, A.M., Casara, G., Battistella, P.A. et al. Acute-onset transient hydrocephalus after suspension of ACTH therapy for infantile spasms: A case report. Ital J Neuro Sci 5, 219–222 (1984). https://doi.org/10.1007/BF02043227
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DOI: https://doi.org/10.1007/BF02043227