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The influence of temperature on the volume effect of dextran 70

  • U. F. Gruber
Article

Summary

The reliability of an infusion of 500 ml cold or room temperature 6% dextran 70 in normal saline as a volume expander was studied in eleven subjects after removal of 500 ml blood. Changes in blood volume were measured directly with the Volemetron-RI131HSA technique and indirectly from changes in hematocrit. Both the cold and warm solutions lead to an immediate volume increase higher than the amount infused. 3 h after infusion the blood volume in both groups had reached the initial value. It is concluded that the temperature of the infusion solution between 4°C–20°C probably does not influence the volume effect of 6% dextran 70 in hypovolemic man.

Keywords

Dextran Blood Volume Volume Effect Massive Transfusion Autologous Plasma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Zusammenfassung

Nach Entzug von 500 ml Blut wurde bei elf gesunden Freiwilligen die Zuverlässigkeit der Volumenexpansion einer Infusion von 500 ml 6% Dextran 70 (Macrodex®) in 0,9% Kochsalzlösung in Abhängigkeit von der Temperatur geprüft. Die Veränderungen des Blutvolumens wurden mittels der Volemetron-RI131HSA-Hämatokrittechnik gemessen. Sowohl die Infusion von kalter (4°C) als auch von warmer (20°C) Dextranlösung führt zu einer initialen Volumenzunahme, die größer ist, als der zugeführten Menge entspricht. 3 Std nach Infusionsbeginn entspricht das Blutvolumen in beiden Gruppen dem Wert vor dem Blutentzug.

Die Temperatur der Infusionslösung beeinflußt im Bereich von 4–20°C den Volumeneffekt von Dextran 70 bei hypovolämischen Erwachsenen wahrscheinlich nicht.

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Literature

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Copyright information

© Springer-Verlag 1967

Authors and Affiliations

  • U. F. Gruber
    • 1
  1. 1.Department of SurgeryUniversity of BaselBürgerspital, Basel

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