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Der Einfluß von Nicotinsäure und Propranolol auf die lipolytische Wirkung von Catecholaminen und Peptidhormonen in vitro

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Zeitschrift für die gesamte experimentelle Medizin einschließlich experimentelle Chirurgie

Zusammenfassung

Es wird über den Einfluß der Nicotinsäure und desβ-Receptorenblockers Propranolol auf die Lipolyse durch Adrenalin, Noradrenalin, ACTH und TSH am epididymalen Fettgewebe der Ratte in vitro berichtet. Nicotinsäure hemmt die lipolytische Wirkung der Catecholamine und der Polypeptidhormone. Derβ-Receptorenblocker hemmt dagegen nur die durch Adrenalin und Noradrenalin induzierte Lipolyse, nicht dagegen die durch ACTH oder TSH. Die Spontanlipolyse blieb durch Nicotinsäure und Propranolol unbeeinflußt. Die Befunde weisen darauf hin, daß der Wirkungsmechanismus der Catecholamine und der Polypeptidhormone auf die Lipolyse verschieden ist.

Summary

The influence of the nicotinic acid and of theβ-adrenergic blocking agent propranolol on the lipolysis induced by epinephrine, norepinephrine, ACTH and TSH in epididymal fat pads of the rat in vitro is investigated. Nicotinic acid blocks the lipolytic action of the catecholamines and the peptide hormones. Theβ-blocking agent only inhibits the catecholamine induced lipolysis, not that induced by ACTH and TSH. Spontaneous lipolysis is influenced neither by nicotinic acid nor by propranolol. It is concluded that the catecholamines act on lipolysis by another mechanism than the peptide hormones do.

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Authors and Affiliations

  1. I. Medizinische Klinik der Universität München, Deutschland

    P. Schwandt, Th. Hartmann & H. J. Karl

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  1. P. Schwandt
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  2. Th. Hartmann
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  3. H. J. Karl
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1-Isopropylamino-3-(1-naphthyloxy)-2-propanol-HCl.

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Schwandt, P., Hartmann, T. & Karl, H.J. Der Einfluß von Nicotinsäure und Propranolol auf die lipolytische Wirkung von Catecholaminen und Peptidhormonen in vitro. Z. Gesamte Exp. Med. 143, 79–84 (1967). https://doi.org/10.1007/BF02042976

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  • DOI: https://doi.org/10.1007/BF02042976

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