Summary
Fifteen juvenile diabetic patients with normal eye fundus, 6 with non proliferative retinopathy, 5 with proliferative retinopathy and 5 healthy control subjects were studied in order to investigate pituitary function in relation to diabetic retinopathy. ACTH values at 0800 and 1800, hPRL and TSH secretion in response to 200 μg TRH i.v., and GH secretion in response to 500 mg oral L-dopa were evaluated. In all diabetic subjects, 0800 ACTH levels were lower than in controls. Basal hPRL, TSH and GH values of the diabetics did not differ from those of the controls. No significant differences were found in hPRL levels in response to TRH, whereas significantly lower TSH responses were found in the diabetics. L-dopa caused a significantly different response of GH in the diabetic subjects compared to controls. There is thus a considerable derangement in pituitary hormone secretion in juvenile diabetes mellitus.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Froland A., Hagen C., Lauritzen E.: Diabetic retinopathy and prolactin - Lancet1, 45, 1977.
Gnudi A., Lugari R., Cavazzini M. G.: Variation of blood glucose and serum growth hormone, prolactin and insulin in subjects with insulin-dependent diabetes, after OGTT and pretreatment with 2-Br-α-ergocryptine - Acta diabet. lat.14, 137, 1977.
Gragnoli G., Palazzuoli V., Favilli R., Tanganelli I., Migliarese G.: Dopaminergic stimulation of HGH in diabetes mellitus and in obesity - Acta diabet. lat.14, 137, 1977.
Gray R. S., Cameron E. H. D., Clarke B. F.: Plasma prolactin response to i.v. arginine in insulin-dependent diabetes - Acta diabet. lat.16, 269, 1979.
Hanssen K. F., Christensen S. E., Hansen Aa. P., Lundbæk K., Torjesen P. A., Weeke J.: Plasma prolactin in juvenile diabetics. 24-h studies with somatostatin - Diabetologia15, 369, 1978.
Harter M., Balarac N., Pourcher P., Koslowski J. M., Krebs B., Ramaioli A.: Diabetic retinopathy and prolactin - Lancet2, 961, 1976.
Hunter P. R., Anderson J., Lunn T. A., Horrobin D. F., Boyns A. R., Cole E. N.: Diabetic retinopathy and prolactin - Lancet1, 1237, 1974.
Koncz L., Soeldner J. S., Balodimos M. C., Boden G., Gleason R. E., Younger D.: Human growth hormone secretion after double stimulation with arginine in normal and insulin-dependent diabetic women - Diabetes22, 694, 1973.
Luft R.: Indications that human growth hormone plays a role in diabetes mellitus and diabetic retinopathy - In:Leibel B. S., Wrenshall G. A. (Eds.): On the nature and treatment of diabetes. Excerpta Medica Foundation, Amsterdam, 1965; p. 496.
Lundbæk K.: Diabetic angiopathy - Acta diabet. lat.10, 183, 1973.
Lundbæk K.: Growth hormone's role in diabetic microangiopathy - Diabetes25 (Suppl. 2), 845, 1976.
Lunbæk K., Christensen N. J., Jensen V. A., Johansen K., Olsen T. S., Hansen A. P., Ørskov H., Østerby R.: The pathogenesis of diabetic angiopathy and growth hormone- Dan. med. Bull.18, 1, 1971.
Mirouze J., Cristol P., Jaffiol C., Badach A.: The metopyrone test in diabetes mellitus - Ann. Endocr. (Paris)23, 481, 1962.
Passa P., Gauville C., Canivet J.: Influence of muscular exercise on plasma level of growth hormone in diabetics with and without retinopathy - Lancet2, 72, 1974.
Powell E. D. U., Frantz A., Rabkin M. T., Field R. A.: Growth hormone in relation to diabetic retinopathy - New Engl. J. Med.17, 922, 1966.
Robuschi G., Gnudi A., Bandini P., Emanuele R., Roti E.: TSH response to TRH in euthyroid insulin-dependent diabetics - Acta diabet. lat.16, 265, 1979.
Sekhuja V., Rastogi G. K., Sialy R.: Growth hormone response to L-dopa in diabetes mellitus - Acta diabet. lat.13, 242, 1976.
Singh A., Kolodny H. D., Sherman L., Benjamin F., Deutsch S.: Inadequate serum growth hormone (SGH) response to L-dopa stimulation in diabetes mellitus - Diabetes22 (Suppl. 1), 300, 1973; abstract #48.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Cerasola, G.A., Donatelli, M., Sinagra, D. et al. Study of pituitary secretion in relation to retinopathy in patients with juvenile diabetes mellitus. Acta diabet. lat 18, 319–328 (1981). https://doi.org/10.1007/BF02042815
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02042815