Abstract
A case of hypokalemic myopathy with systolic hypertension due to chronic liquorice ingestion is described. The clinical features quickly receded on potassium replacement therapy and discontinuation of liquorice ingestion. The relationship between the clinical features and the blood values and instrumental data is shown. The aldosterone-like action of the active principle of liquorice is underlined.
Sommario
Riportiamo un caso di Miopatia ipocaliemica con ipertensione arteriosa da protratta assunzione di liquerizia. La sintomatologia clinica regredisce prontamente con la somministrazione di terapia sostitutiva e sospensione dell' assunzione del fattore causale. Si evidenzia la correlazione tra sintomatologia clinica e dati ematochimici e strumentali. Si sottolinea inoltre l'azione aldosteronesimile del principo attivo della liquerizia.
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References
Conn, J.W.,Rovner, R.D.,Cohen, E.L.:Liquorice-induced pseudoaldosteronism. JAMA, 492–496, 1968.
Cumming A.L.M.:Metabolic effects of liquorice, British Med. J., 1, 906, 1977.
Groen J., Pelser H., Frenkel, M., Kamminga C.E., Willebrands A.F.:Effects of Glycyrrhizinic acid on the electrolyte metabolism in Addison's disease. New Engl. J. Med., 244, 471–475, 1951.
Gross E.G., Dexter, J.D., Roth R.G.:Hypokalemic myopathy with myoglobinuria associated with liquorice ingestion. New Engl. J. Med., 274, 602–606, 1966.
Hashimoto S., Akai F., Semba E., Sakatani K., Hiruma S., Nagaoka M., Hukuda K., Imada A.:Neuronal changes of hypokalemic myopathy; J. Neurol. Sci., 44, 169–179, 1980.
Nightingale S., Smith, P.E., Turnbull, D.M.:Anorexia nervosa, liquorice and hypokalemic myopathy; Postgrad. Med. J., 57; 577–579, 1981.
Molhuisen J.A., Gerbrandy J., De Vries L.A., De Jong J.G., Lenstra J.B., Turner K.P., Borst, J.G.G.:A liquorice extract with desoxycorticosterone-like action. Lancet, 2, 381–386, 1950.
Sundarm M.B.M., Swamirathan R.:Total body potassium depletion and severe myopathy due to chronic liquorice ingestion. Postgrad. Med. J., 57, 48–49, 1981.
Van Horn, G., Drori, J.B., Schwarz, F.D.:Hypokalemic myopathy and elevation of serum enzymes, Arch. Neurol., 44, 169–179, 1980.
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Cibelli, G., De Mari, M., Pozio, G. et al. Hypokalemic myopathy associated with liquorice ingestion. Ital J Neuro Sci 5, 463–466 (1984). https://doi.org/10.1007/BF02042634
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DOI: https://doi.org/10.1007/BF02042634