Nuclear methods of analysis applied to quantitation in laser microprobe mass spectrometry
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Laser microprobe mass spectrometry (LMMS) detection limits for mercury have been determined using mercury-doped Spurr's tissue embedding medium. Actual mercury concentrations were confirmed via INAA. Procedures have also been developed to measure lithium and indium concentrations in thin films of polymerized Spurr's samples via PIGE and PIXE. These elements are currently being investigated as laser power density internal standards in the analysis of human tissue for studies of trace element involvement in neurological diseases.
KeywordsIndium Thin Film Mass Spectrometry Mercury Lithium
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- 1.A. H. VERBUEKEN, F. J. BRUYMSEELS, R. E. VAN GROEKEN, F. ADAMS, Laser Microprobe Mass Spectrometry, in: Inorganic Mass Spectrometry, F. ADAMS, R. GOKBELS, R. VAN GRIEKEN (Eds), New York, John Wiley and Sons, p. 173.Google Scholar
- 2.A. H. VERBUEKEN, R. E. VAN GRIEKEN, Anal. Chem., 56 (1984) 1362.Google Scholar
- 5.A. R. SPURR, J. Microscopic Biol. Cell, 22 (1975) 287.Google Scholar
- 6.J. L. CAMPBELL, A. PERUJO, W. J. TEESDALE, J. A. MAXWELL, Scanning Electron Microscopy, VI (1987) 1631.Google Scholar
- 7.R. KAUFMANN, Laser microprobe mass analysis (LAMMA): Current state of the art with special emphasis on biomedical applications, in: Microbeam Analysis, K. F. J. HEINRICH (Ed.), San Francisco Press, San Francisco, 1982, p. 341.Google Scholar
- 8.W. D. EHMANN, W. R. MARKESBERY, M. ALAUDDIN, T. I. M. HOSSAIN E. H. BRUBAKER Neutrotoxicology, 7 (1986) 197.Google Scholar
- 9.L. A. CURRIE, Anal. Chem., 40 (1968) 586.Google Scholar