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A general approach to the chromatographic behaviour of125I-labelled iodothyronines and tyrosine methyl ester derivatives of steroids

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Abstract

The separation of low molecular weight compounds labelled with125I has gained importance with the advent of radioimmunoassay (RIA) in which overwhelmingly125I-labelled analytes are used as tracers. The chloramine T labelling method proved to be the most suitable procedure to introduce radioiodine atom via aromatic electrophilic substitution either in the thyronine molecule or in the tyrosine methyl ester (TME) side chain coupled as a prosthetic group to different compounds which do not possess phenolic hydroxyl groups.

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Authors and Affiliations

  1. Institute of Isotopes of the Hungarian Academy of Sciences, P.O.B. 77, H-1525, Budapest, (Hungary)

    G. Tóth

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  1. G. Tóth
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Tóth, G. A general approach to the chromatographic behaviour of125I-labelled iodothyronines and tyrosine methyl ester derivatives of steroids. Journal of Radioanalytical and Nuclear Chemistry Articles 121, 17–27 (1988). https://doi.org/10.1007/BF02041443

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  • DOI: https://doi.org/10.1007/BF02041443

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