Multiple tritium labelling of thymine and its derivatives

  • G. V. Sidorov
  • N. F. Myasoyedov
Article

Abstract

The paper deals with the synthesis of thymine and its derivatives carrying the label at C(6) in the pyrimidine in the methyl group and in deoxy-d-ribose. The molar activity of the preparations ranges from 0.85 to 4.94 PBq/mol. A procedure is proposed for obtaining tritium-labelled thymine compounds: nucleoside, nucleoside mono-, di- and triphosphates.

Keywords

Methyl Physical Chemistry Inorganic Chemistry Pyrimidine Nucleoside 

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References

  1. 1.
    E. K. IVANKOVA, G. V. SIDOROV, N. F. MYASOEDOV, Radiokhimiya, 23 (1981) 296.Google Scholar
  2. 2.
    N. F. MYASOEDOV, O. B. KUZNETSOVA, E. K. IVANKOVA, G. V. SIDOROV, O. YU. SOBOLEVA, Organicheskie soedineniya, mechenye radioaktivnymi izotopami, CZKAE, Praha, 1977, p. 125.Google Scholar
  3. 3.
    N. F. MYASOEDOV, G. V. SIDOROV, Radiokhimiya, 22 (1980) 574.Google Scholar
  4. 4.
    N. F. MYASOEDOV, G. V. SIDOROV, O. B. KUZNETSOVA, M. D. FRANK-KAMENETSKAYA, T. YU. LAZURKINA, V. A. ORLOVA, Radiokhimiya, 26 (1984) 341.Google Scholar
  5. 5.
    L. A. YAKOVLEVA, YU. L. KAMINSKYI, L. P. SOSNOVA, A. I. NAGORNYI, Organicheskie soedineniya, mechenye radioaktivnymi izotopami, Cniiatominform, Moskva, 1982, p. 255.Google Scholar
  6. 6.
    R. E. CLINNE, R. M. FINK, K. FINK, J. Amer. Chem. Soc., 81 (1959) 2521.Google Scholar
  7. 7.
    R. BROSSMER, D. ZIEGLE, Tetrahedron Lett., 43 (1966) 5233.Google Scholar

Copyright information

© Akadémiai Kiadó 1988

Authors and Affiliations

  • G. V. Sidorov
    • 1
  • N. F. Myasoyedov
    • 1
  1. 1.Institute of Molecular GeneticsUSSR Academy of SciencesMoscowUSSR

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