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Natural killer cell activity in inflammatory joint disease

Clinical Rheumatology volume 2, pages 243–249 (1983)Cite this article

Summary

The natural killer (NK) cell activity of unfractionated peripheral blood and synovial fluid mononuclear cells from patients with inflammatory joint disease was measured in a short-term assay using the human tumour cell line, K562, as the target. The mean values for peripheral blood NK activity of the various groups (controls, rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA)) were similar although the rheumatoid group showed the widest range. However, the NK activity of PsA patients (23.74 ± 10.14) was significantly lower than that of the controls (31.63 ± 10.8, 0.05, P>0.01). Almost without exception, NK activity was found to be considerably lower in synovial fluid than in paired blood samples (p<0.01).

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References

  1. West, W.H., Cannon, G.B., Kay, H.D., Bonnard, G.D., Herberman, R.B. Natural cytotoxic reactivity of human lymphocytes against a myeloid cell line: characteristics of effector cells. J Immunol, 1977, 118, 355–361.

    PubMed  CAS  Google Scholar 

  2. Herberman, R.B., Djeu, J.Y., Kay, H.D., Ortaldo, J.R., Riccardi, C., Bonnard, G.D., Holden, H.T., Fagnani, R., Santoni, A., Puccetti, P. Natural killer cells: characteristics and regulation of activity. Immunol Rev, 1979, 44, 43–70.

    PubMed  CAS  Google Scholar 

  3. Santoli, D., Trinchieri, G., Kaprowski, H. Cell-mediated cytotoxicity against virus-infected target cells in humans. II. Interferon induction and activation of natural killer cells. J Immunol, 1978, 121, 532–538.

    PubMed  CAS  Google Scholar 

  4. Kiessling, R., Petranyi, G., Klein, G., Wigzell, H. Genetic variation of in vitro cytolytic activity and in vivo rejection potential of non-immunised semi-syngeneic mice against a mouse lymphoma line. Int J Cancer, 1975, 15, 933–940.

    PubMed  CAS  Google Scholar 

  5. Warner, N.L., Woodruff, M.F.A., Burton, R.C. Inhibition of the growth of lymphoid tumours in syngeneic (athymic) nude mice. Int J Cancer, 1977, 20, 146–155.

    PubMed  CAS  Google Scholar 

  6. Hanna, N., Fidler, I.J. Role of natural killer cells in the destruction of circulating tumour emboli. JNCI, 1980, 65, 801–809.

    PubMed  CAS  Google Scholar 

  7. Karre, K., Klein, G.O., Kiessling, R., Klein, G., Roder, J.C. Low natural in vivo resistance to syngeneic leukaemias in natural killer-deficient mice. Nature, 1980, 284, 624–626.

    Article  PubMed  CAS  Google Scholar 

  8. Talmadge, J.E., Meyers, K.M., Prieur, D.J., Starkey, J.R. Role of NK cells in tumour growth and metastasis in beige mice. Nature, 1980, 284, 622–624.

    Article  PubMed  CAS  Google Scholar 

  9. Collins, J.L., Patek, P.Q., Cohn, M. Tumorigenicity and lysis by natural killers. J Exp Med, 1981, 153, 89–106.

    Article  PubMed  CAS  Google Scholar 

  10. Haliotis, T., Roder, J., Klein, M., Ortaldo, J., Fauci, A.S., Herberman, R.B. Chediak-Higashi gene in humans. I. Impairment of natural-killer function. J Exp Med, 1980, 151, 1039–1048.

    Article  PubMed  CAS  Google Scholar 

  11. Trinchieri, G., Santoli, D. Antiviral activity induced by culturing lymphocytes with tumor-derived or virus-transformed cells. Enhancement of human natural killer cell activity by interferon and an antagonistic inhibition of susceptibility of target cells to lysis. J Exp Med, 1978, 147, 1314–1333.

    Article  PubMed  CAS  Google Scholar 

  12. Gidmund, M., Orn, A., Wigzell, H., Senik, A., Gresser, I. Enhanced NK cell activity in mice injected with interferon and interferon-inducers. Nature, 1978, 273, 759–61.

    Article  PubMed  Google Scholar 

  13. Herberman, R.B., Ortaldo, J.R., Bonnard, G.D. Augmentation by interferon of human natural and antibody-dependent cell-mediated cytotoxicity. Nature, 1979, 277, 221–223.

    Article  PubMed  CAS  Google Scholar 

  14. Moore, M., Potter, M.R. Enhancement of human natural cell-mediated cytotoxicity by interferon. Br J Cancer, 1980, 41, 378–87.

    PubMed  CAS  Google Scholar 

  15. Appleford, D.J.A., Denman, A.M. Fate of herpes simplex virus in lymphocytes from inflammatory joint effusions. I. Failure of virus to grow in cultured lyphocytes. Ann Rheum Dis, 1979, 38, 443–449.

    PubMed  CAS  Google Scholar 

  16. Appleford, D.J.A., Denman, A.M. Fate of herpes simplex virus in lyphocytes from inflammatory joint effusions. II. mechanism of non-permissiveness. Ann Rheum Dis, 1979, 38, 450–455.

    PubMed  CAS  Google Scholar 

  17. Penschow, J., MacKay, I.R. NK and K cell activity of human blood; differences according to sex, age and disease. Ann Rheum Dis, 1980, 39, 82–86.

    PubMed  CAS  Google Scholar 

  18. MacLennan, I.C.M., Loewi, G. The cytotoxic activity of mononuclear cells from joint fluid. Clin Exp Immunol, 1970, 6, 713–720.

    PubMed  CAS  Google Scholar 

  19. MacLennan, I.C.M., Loewi, G., The effect of peripheral lymphocytes from patients with inflammatory joint disease on human target cells in vitro. Clin Exp Immunol, 1968, 3, 385–391.

    PubMed  CAS  Google Scholar 

  20. Burmester, G.R., Kalden, J.R., Peter, H.H., Schedel, I., Beck, P., Wittenborg, A. Immunological and functional characteristics of peripheral blood and synovial fluid lymphocytes from patients with rheumatoid arthritis. Scand J Immunol, 1978, 7, 405–417.

    PubMed  CAS  Google Scholar 

  21. Boyum, A. Isolation of mononuclear cells and granulocytes from human blood. Scand J Clin Lab Invest, 1968, 21 (suppl. 97), 77–89.

    PubMed  CAS  Google Scholar 

  22. Timonen, T., Saksela, E., Rankin, A., Hayry, P. Fractionation, morphological and functional characterisation of effector cells responsible for human natural killer cell activity against cell-line targets. Cell Immunol, 1979, 48, 133–148.

    Article  PubMed  CAS  Google Scholar 

  23. Timonen, T., Ortaldo, J.R., Herberman, R.B. Characterisation of human granular lymphocytes and relationship to natural killer and K cells. J Exp Med, 1981, 153, 569–582.

    Article  PubMed  CAS  Google Scholar 

  24. Hoffman, T. Natural killer function in systemic lupus erythematosus. Arthritis Rheum, 1980, 23, 30–35.

    PubMed  CAS  Google Scholar 

  25. Oshimi, K., Sumiya, M., Gonda, N., Kano, S., Takaku, F. Natural killer cell activity in systemic lupus erythematosus. Lancet, 1979, ii, 1023.

    Article  Google Scholar 

  26. Goto, M., Tanimoto, K., Horiuchi, Y. Natural cell mediated cytotoxicity in systemic lupus erythematosus. Suppression by antilymphocyte antibody. Arthritis Rheum, 1980, 23, 1274–1281.

    PubMed  CAS  Google Scholar 

  27. Gupta, S., Good, R.A. Subpopulation of lymphocytes. I. Studies in Immunodeficient Patients. Clin Exp Immunol, 1977, 30, 222–228.

    PubMed  CAS  Google Scholar 

  28. Hooks, J.J., Moutsopoulos, H.M., Geis, S.A., Stahl, N.I., Decker, J.L., Notkins, A.L. Immune interferon in the circulation of patients with autoimmune disease. NEJM, 1979, 301, 5–8.

    PubMed  CAS  Google Scholar 

  29. Hooks, J.J., Jordan, G.W., Cupps, T., Moutsopoulos, H.M., Fauci, A.S., Notkins, A.L. Multiple interferons in the circulation of patients with systemic lupus erythematosus and vasculitis. Arthritis Rheum, 1982, 25, 396–400.

    PubMed  CAS  Google Scholar 

  30. Ytterberg, S.R., Schnitzer, T.J., Serum interferon levels in patients with systemic lupus erythematosus. Arthritis Rheum, 1982, 25, 401–406.

    PubMed  CAS  Google Scholar 

  31. Dobloug, J.H., Forre, O., Kvien, T.R., Eegeland, T., Degre, M. Natural killer (NK) cell activity of peripheral blood, synovial fluid and synovial tissue lymphocytes from patients with rheumatoid arthritis and juvenile rheumatoid arthritis, Ann Rheum Dis, 1982, 41, 490–494.

    PubMed  CAS  Google Scholar 

  32. Goto, M., Tanimoto, K., Chihara, T., Horiuchi, Y. Natural cell-mediated cytotoxicity in Sjogren's syndrome and rheumatoid arthritis. Arthritis Rheum, 1981, 24, 1377–1382.

    PubMed  CAS  Google Scholar 

  33. Karsh, J., Dorval, G., Osterland, C.K., Natural cytotoxicity in rheumatoid arthritis and systemic lu pus erythematosus. Clin Immunol, Immunopathol 1981, 19, 437–446.

    CAS  Google Scholar 

  34. Silver, R.M., Redelman, D., Zvaifler, N.J. Naides, S. Studies of rheumatoid synovial fluic lymphocytes. I. Evidence for activated natural killer-(NK) like cells. J. Immunol., 1982, 128, 1758–1763.

    PubMed  CAS  Google Scholar 

  35. Panayi, G.S., Corrigall, V. In: Immunopathoge nesis of rheumatoid arthritis. Eds. Panayi, G.S. Johnson, P.M. Reedbooks Ltd., Chertsey, Surrey 1979, 31–36.

    Google Scholar 

  36. Fox, R.I., Fong, S., Sabharwal, N., Carstens S.A., Kung, P.C., Vaughan, J.H. Synovial fluio lyphocytes differ from peripheral blood lympho cytes in patients with rheumatoid arthritis. J Immunol, 1982, 128, 351–354.

    PubMed  CAS  Google Scholar 

  37. Fraser, J.R.E., Tait, B., Aaskon, J.G., Cunningham, A.L. Possible genetic determinants in epidemic polyarthritis caused by Ross River virus ir fection. Aust NZ J Med, 1980, 10, 597–603.

    CAS  Google Scholar 

  38. Armstrong, R.D., Panayi, G.S., Welsh, K.I. Histo compatibility antigens in psoriasis, psoriatic arthro pathy and ankylosing spondylitis. Ann Rheum Dis 1983, 42, 142–146.

    PubMed  Article  CAS  Google Scholar 

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  1. Departments of Medicine and Rheumatology, Guy's Hospital, SEI 9RT, London, UK

    R. D. Armstrong & G. S. Panayi

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  1. R. D. Armstrong
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  2. G. S. Panayi
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Armstrong, R.D., Panayi, G.S. Natural killer cell activity in inflammatory joint disease. Clin Rheumatol 2, 243–249 (1983). https://doi.org/10.1007/BF02041398

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  • DOI: https://doi.org/10.1007/BF02041398

Key Words

  • Natural Killer
  • Rheumatoid Arthritis
  • Ankylosing Spondylitis
  • Psoriatic Arthritis