Skip to main content
SpringerLink
Log in

Chemical characterization of complexation behavior of pertechnetate with cysteine

  • Published:
Journal of Radioanalytical and Nuclear Chemistry Aims and scope Submit manuscript

Abstract

The labeling behavior of cysteine with99TcO −4 ion and/or99mTcO −4 ion at different cysteine concentrations reductant and pH values has been studied by chromatography, and the labeling yield was calculated. Three major Tc-complexes, yellow, reddish brown and green can be separated by gel filtration chromatography (GFC). Thin layer chromatography (TLC), high performance liquid chromatography (HPLC) and ion-exchange chromatography (IC) were used to separate the complexes collected from GFC. The TLC, HPLC data show the pertechnetate accompanied with a yellow complex; the green and purple complex contain more than two complexes. Electrophoresis and IC data show that the complexes carry a negative charge. The conductivity, UV-VIS, flow beta-detector with HPLC and autoradiography are also applied to analyze complex formation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. A. DAVISON, The coordination chemistry of technetium, in E. DEUTSCH, M. NICOLINI, and H. N. WAGNER (Eds), Technetium in Chemistry and Nuclear Medicine, New York, NY, Raven, 1983, p. 3.

    Google Scholar 

  2. R. D. PEACOCK, The Chemistry of Technetium and Rhenium. Elsevier Publishing Company, NY, 1966, p. 13.

    Google Scholar 

  3. M. K. DEWANJEE, Semi. Nucl. Medic., 20(1) (1990) 5.

    Google Scholar 

  4. C. BRATU, G. H. BRATU, I. GALATEANU, M. ROMAN, J. Radioanal. Chem., 26 (1975) 5.

    Google Scholar 

  5. A. DAVISON, The coordination chemistry of technetium, in E. DEUTSCH, M. NICOLINI, and H. N. WAGNER (Eds), Technetium in Chemistry and Nuclear Medicine, New York, NY, Raven, 1983, p. 29.

    Google Scholar 

  6. M. TUBIS, J. S. ENDOW, Int. J. Appl. Radiation Isotopes, 19 (1968) 835.

    Article  Google Scholar 

  7. A. YOKOYAMA, K. HORIUCHI, Int. J. Appl. Radiation Isotopes, 33 (1982) 929.

    Article  Google Scholar 

  8. A. YOKOYAMA, H. SAJI, H. TANAKA, T. ODORI, R. MORITA, T. MORI K. TORIZUKA, J. Nucl. Medic., 17(9) (1976) 810.

    Google Scholar 

  9. B. JOHANNSEN, R. SYHRE, H. SPIES, R. MUNZE, J. Nucl. Medic., 19 (1978) 816.

    Google Scholar 

  10. R. GOTO, M. TEZUKA, O. TAMEMASA, Chem. Pharm. Bull., 25 (1977) 1574.

    PubMed  Google Scholar 

  11. Y. KARUBE, T. MAEDA, M. OHYA, S. SUGATA, A. KONO, Y. MATSUAHIMA, Chem. Pharm. Bull., 29 (1981) 2385.

    PubMed  Google Scholar 

  12. Y. KARUBE, T. MAEDA, M. OHYA, S. SUGATA, A. KONO, Y. MATSUAHIMA, J. Radiat. Res., 23 (1982) 234.

    PubMed  Google Scholar 

  13. M. TUBIS, G. T. KRISHNAMURTHY, J. S. ENDOW, W. H. BLAHD, J. Nucl. Medic., 13(8) (1982) 652.

    Google Scholar 

  14. B. M. BOWEN, D. R. HENDERSON, J. E. KELLAM, D. E. WOOD, Am. J. Hops. Pharm., 29 (1972) 502.

    Google Scholar 

  15. A. TAKEDA, S. OKADA, Intern. J. Appl. Radiation Isotope, 40(7) (1989) 565.

    Article  Google Scholar 

  16. A. TAKEDA, S. GOTO, S. OKADA, Chem. Pharm. Bull., 36 (1988) 2570.

    PubMed  Google Scholar 

  17. O. TAMEMASA, R. GOTO, S. OKADA, Annals Nucl. Medic., 2 (1988) 55.

    Google Scholar 

  18. A. TAKEDA, R. GOTO, S. OKADA, Annals Nucl. Medic., 2 (1988) 55.

    Google Scholar 

  19. S. OKADA, A. TAKEDA, Proc. 6th Intern. Symp. on Radiopharmacology, 1990, p. 88.

  20. P. J. ROBBINS, Chromatography of Technetium-99m Radiopharmaceutical Guide, Society of Nuclear Medicine, NY, 1985.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Nuclear Science, National Tsing Hua University, 30043, Hsinchu, Taiwan, (R. O. C.)

    Ai-Yih Wang, Jiunn-Liang Lin & Jiunn-Guang Lo

  2. Institute of Nuclear Energy Research, P. O. Box 3-27, 32500, Lung-tan, Taiwan (R. O. C.)

    Zei-Tsan Tsai

Authors
  1. Ai-Yih Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jiunn-Liang Lin
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jiunn-Guang Lo
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Zei-Tsan Tsai
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wang, AY., Lin, JL., Lo, JG. et al. Chemical characterization of complexation behavior of pertechnetate with cysteine. Journal of Radioanalytical and Nuclear Chemistry, Articles 159, 129–144 (1992). https://doi.org/10.1007/BF02041026

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02041026

Keywords

Search

Navigation