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Characterization and use of a gamma radiation TLC scanner for radiochemical purity measurements of radiopharmaceutical kit preparations of99mTc(dmpe)2Cl +2

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Abstract

A simple, low cost TLC scanner system for the characterization of γ-emitting radiopharmaceuticals is described. The TLC γ scanner has a linear response range of ∼0.074 Mbq up to ≥2.94 Mbq. The accuracy and reproducibility of measurement is better than ±5% (relative). The utility of this TLC scanner system is demonstrated by application to the radioanalytical evaluation of99mTc(dmpe)2Cl +2 preparations. A comparison with HPLC radioanalytical separations is made.

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References

  1. G. ZWEIG, J. SHERMA, Anal. Chem., 52 (1980) 276R.

    Article  Google Scholar 

  2. H. J. ISSAG, J. Liq. Chrom., 4 (1981) 955.

    Google Scholar 

  3. H. J. ISSAG, J. Liq. Chrom., 3 (1980) 1435.

    Google Scholar 

  4. HPTLC; A. ZLATKIS, R. E. KAISER, (Eds), Elsevier, Amsterdam, The Netherlands; 1977.

  5. G. GUICHON, F. BRESSABLE, A. SIOUFFI, J. Chrom. Sci., 17 (1979) 368.

    Google Scholar 

  6. M. PROSEK, A. MEDJA, E. KUCAN, M. KATIC, M. BANO, J. HRC and CC, 2 (1979) 517.

    Google Scholar 

  7. D. JÄNCHEN, H. R. SCHMUTZ, J. HRC and CC; 1 (1979) 133.

    Google Scholar 

  8. K. A. KROHN, A. L. JANSHALT, Int. J. Appl. Radiation Isotopes, 28 (1977) 213.

    Article  Google Scholar 

  9. R. E. BISH, D. SILVERSTEIN, J. I. BEDE, J. Radioanal. Chem., 57 (1980) 565.

    Google Scholar 

  10. USP XX, The United States Pharmacopeia, National Formulary NF XV, 1980, p. 762.

  11. P. J. ROBBINS, Chromatography of Technetium-99m Radiopharmaceuticals—A Practical Guide; Society of Nuc. Med. Publishers; N. Y., N. Y., 1983, p. 35.

    Google Scholar 

  12. T. PINKERTON, D. FERGUSON, E. DEUTSCH, W. R. HEINEMAN, K. LIBSON, Int. J. Appl. Radiation Isotopes 33 (1982) 907.

    Article  Google Scholar 

  13. S. C. SRIVASTAVA, D. BANDYOPADHYAY, G. MEINKEN, P. RICHARDS, 28th Society of Nuclear Medicine meeting abstracts, 1981.

  14. A. NUNN, J. Chrom., 255 (1983) 91.

    Article  Google Scholar 

  15. M. D. LOBERG, A. D. NUNN, D. W. PORTER, in Nuclear Medicine Annual, L. M. FREEMAN, H. S. WEISSMAN, (Eds), Raven Press Publications; New York; 1981.

    Google Scholar 

  16. A. R. FRITZBERG, D. LEWIS, J. Nucl. Med., 21 (1980) 1180.

    PubMed  Google Scholar 

  17. E. DEUTSCH, J. Nuc. Med., 23 (1982) 1093.

    Google Scholar 

  18. A. L. JANSHOLT, K. A. KROHN, D. R. VERA, H. H. HINES, J. Nuc. Med. Tech., 8 (1980) 222.

    Google Scholar 

  19. B. L. KARGER, L. R. SNYDER, C. HORVATH, An Introduction to Separation Science, Wiley Interscience Publication, John Wiley & Sons New York, New York, 1973, p. 149.

    Google Scholar 

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Authors and Affiliations

  1. New England Nuclear, Radiopharmaceuticals Research Department, 331 Treble Cove Road, 01862, N. Billerica, Mass., (USA)

    A. P. Carpenter Jr., T. J. Mysliwy, S. I. Sivakoff, M. N. Doshi, E. M. Wolshin, M. A. Matthew, G. H. Schnaper, V. Subramanyam & L. L. Camin

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  1. A. P. Carpenter Jr.
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  2. T. J. Mysliwy
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  3. S. I. Sivakoff
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  4. M. N. Doshi
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  5. E. M. Wolshin
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  6. M. A. Matthew
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  7. G. H. Schnaper
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  8. V. Subramanyam
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  9. L. L. Camin
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Carpenter, A.P., Mysliwy, T.J., Sivakoff, S.I. et al. Characterization and use of a gamma radiation TLC scanner for radiochemical purity measurements of radiopharmaceutical kit preparations of99mTc(dmpe)2Cl +2 . Journal of Radioanalytical and Nuclear Chemistry, Articles 89, 435–446 (1985). https://doi.org/10.1007/BF02040607

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  • DOI: https://doi.org/10.1007/BF02040607

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