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Simple preparation of76Br,123I and211At labeled 5-halo-2′-deoxyuridine

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Abstract

A fast and easy method for the preparation of radiolabeled 5-halo-2′-deoxyuridine (halo=[76Br], [123I] and [211At]) is presented. Labeling is accomplished by oxidation of the halogenide with Iodogen for [123I] and [211At], and Chloramine-T (CAT) for [76Br] followed by halodestannylation of 5-trimethylstannyl-2′-deoxyuridine (TMSUdR). The reaction takes 1 minute giving >90% yield for all three halogens.

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Authors and Affiliations

  1. Institute for Medical Radiobiology, Paul Scherrer Institute, CH-5232, Villigen PSI, Switzerland

    J. Koziorowski & R. Weinreich

  2. Department of Organic Chemistry, Institute of Chemistry, Box 531, S-751 21, Uppsala, Sweden

    J. Koziorowski

Authors
  1. J. Koziorowski
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  2. R. Weinreich
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Koziorowski, J., Weinreich, R. Simple preparation of76Br,123I and211At labeled 5-halo-2′-deoxyuridine. J Radioanal Nucl Chem 219, 127–128 (1997). https://doi.org/10.1007/BF02040279

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  • DOI: https://doi.org/10.1007/BF02040279

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