Advertisement

Development of labelled somatostatin and its analogues for the diagnosis and treatment of tumors

  • Y. M. Liu
Radiopharmaceuticals, Labelled Compounds and RIA
  • 30 Downloads

Abstract

For recent years, the labeling and application of Somatostatin and Its Analogues have been becoming more and more important in the both diagnosis and treatment of a variety of tumors, especially the neuroendocrine tumors. This paper's goals are to deal with the chemical aspects of the radiolabeling of somatostatin and its analogues. It reviews the selected radionuclides and bifunctional chelating agents may be used in the labeling of Somatostatin and its analogues with metal radionuclides. The prospects of application of the Labelled Somatostatin and its analogues are comparatively assessed.

Keywords

Physical Chemistry Inorganic Chemistry Radionuclide Neuroendocrine Tumor Chemical Aspect 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    E.P. Kreening, W.H. Bakker, W.A.P. Breeman, J.W. Koper, P.P.M. Kooij, Ausema L., Ameris JS, Reubi JC, Lamberts SWJ, Lancet 1 (1989) 242.PubMedGoogle Scholar
  2. 2.
    R.O. Dillman, Ann. Intern. Med. 111(1989)5.Google Scholar
  3. 3.
    W.H. Bakker, E.P. Krenning, W.A.P. Breeman, Koper JW, Koojj PPM, Lameris JS Reubi J-C, Visser TJ, Lamberts SWJ, J. Nucl. Med. 32(1991)1184.PubMedGoogle Scholar
  4. 4.
    R.Z. Cai, B. Szoke, R. Lu, D. Fu, T.W. Redding, Schally AV, 83(1986)1896.Google Scholar
  5. 5.
    Anderson et al. Proc Xth Int Symp radiopharmaceutical chem. (1993)362.Google Scholar
  6. 6.
    J.L. Humm, J. Nucl. Med. 27(1986)1490.PubMedGoogle Scholar
  7. 7.
    A.E. Bolton, W.M. Hunter, Biochem. J. 133(1973)529(1973).PubMedGoogle Scholar
  8. 8.
    J.C. Reubi, A.M. Landolt, J. Clin. Endocrinal. Metab. 59(1984)1148.Google Scholar
  9. 9.
    E. Moyse, M. Le Dafniet, J. Epelbaum, P. Pagesy, F. Peiuon, C. Kordon, Enjalbert, J. Clin. Endocrind. Metab. 61(1985)98.Google Scholar
  10. 10.
    S. Ikuyama, H. Nawata, K. Kato, T. Karashima, H. Ibayashi, H. Nagkagaki, J. Clin. Endocrinol. Metab. 61(1985)666(1985).PubMedGoogle Scholar
  11. 11.
    S.W.J. Lamberts, E.P. Krenning, W.H. Bakker, W.A.P. Breeman, P.M. Kocy, J.C. Reubi, Blackwell Scientific Publications, 285.Google Scholar
  12. 12.
    N. Bazzoni, M. Arosio, B. Ambrosio, A. Spada, F. Spinelli-Ressi, R. Sara, C. Bonino, Lunghi, G. Faglia, J. Endocrinol. Invest. 14(suppl.1)17.Google Scholar
  13. 13.
    P.M. Maton, T.M. O'Dorisio, B.A. Howe, N. Engl. J. Med. 312(1985)17.PubMedGoogle Scholar
  14. 14.
    J.V. Anderson, S.R. Bloom, Scand. J. Gastroenterol. 21(1986)115.Google Scholar
  15. 15.
    T.M. O'Dorisio, Am. J. Med 81 1.Google Scholar
  16. 16.
    J.C. Reubi, W.H. Hacki, S.W.J. Lamberts, J. Clin. Endocrinol. metab. 65(1987)1127.PubMedGoogle Scholar
  17. 17.
    S.W.J. Lamberts, W.H. Bakker, J.C. Reubi, E.P. Krenning, N. Engl. J. Med. 323(1990)1246.PubMedGoogle Scholar
  18. 18.
    C.G. Moertel, J. Clin. Oncol, 5(1987)1503.Google Scholar
  19. 19.
    L.K. Kvols, C.G. Moertel, M.J. O'Connell, A.J. Schutt, J. Rubin, R.G. Hahn N. Engl. J. Med. 315(1986)663.PubMedGoogle Scholar
  20. 20.
    J.C. Reubi, J.A. CHayvialle, B. Franc, R. Cohen, C. Calmettes, E. Moding, Lab. Invest 64(1991)65.PubMedGoogle Scholar
  21. 21.
    J.E. Taylor, D.H. Coy, J.P. Moreau, Life Sci., 43(1988)421.PubMedGoogle Scholar
  22. 22.
    V.M. Macaulay, I.E. Smith, M.J. Everard, J.D. Teale, J.C. Reubi, J.L. Millar, Br.J. Cancer.Google Scholar
  23. 23.
    J.E. Taylor, A.E. Bcgden, J.P. Moreau, D.H. Coy, Biochem Biophys. Res. Commun. 153(1988)81.PubMedGoogle Scholar
  24. 24.
    D.J. Kwekkeboom, E.P. Krenning, W.H. Bakker, H.Y. Oei, T.A.W. Spliter, G.S. Kho, S.W. J. Lamberts, J. Nucl. Med.Google Scholar
  25. 25.
    C. Daumas-Duport, B. Scheithauer, J. O'Fallon, P. Kelly, Cancer 62(1988)2152.PubMedGoogle Scholar
  26. 26.
    D.J. Kwekkeboom, A.M. Hoff, S.W.J. Lamberts et al. submitted.Google Scholar
  27. 27.
    Van Eyck, C.H.J., E.P. Krenning, A. Bootsma, W.H. Bakker, H.Y. Oei, R. Van Pel, J. Jeekel, J.C. Reubi, and S.W.J. Lamberts submitted.Google Scholar
  28. 28.
    J.C. Reubi, L. Kvols, E.P. Krenning, S.W.J. Lamberts, Metabolism 39(1990)78.PubMedGoogle Scholar
  29. 29.
    J.C. Reubi, E.P. Krenning, S.W.J. Lamberts, L. Kvols, J. Steroid Biochem. Ml. Biol. 37(1990)1073.Google Scholar
  30. 30.
    R. Scicchitano, P. Dazin, J. Bienenstock, D.G. Payan, A.M. Stanisz, Immunol 1(1987)173.Google Scholar

Copyright information

© Akadémiai Kiadó 1996

Authors and Affiliations

  • Y. M. Liu
    • 1
  1. 1.Department of IsotopesCIAEBeijing(P.R. China)

Personalised recommendations