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Kinetic analysis of99mTc-d, 1-HMPAO decomposition and the method of stabilization

  • Radiopharmaceuticals, Labelled Compounds and RIA
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Abstract

The kinetics of99mTc-d, 1-HMPAO decomposition is studied using home kits. The results showed that99mTc-d, 1-HMPAO decomposition is a first-order reaction. The decomposition constant k is found to be 0.017±0.007h−1 under the experimental conditions of 20°C, 185MBq/ml, pH 7.0. The stability of99mTc-d, 1-HMPAO is affected not only by pH and radioactive concentration, but also by temperature. Using Immol/l gentisic acid as a stabilizer, 740MBq/ml of99mTc-d, 1-HMPAO can be stabilized for 3h with the radiochemical purity above 80%.

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Authors and Affiliations

  1. Chinese PLA General Hospitals, 100853, Beijing, (P.R. China)

    Zhang Jinming, Tian Jiahe & Wang Shengcai

  2. China Institute of Atomic Energy, 102413, Beijing, (P. R. China)

    Lin Qiongfang & Jin Xiaohai

Authors
  1. Zhang Jinming
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  2. Tian Jiahe
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  3. Lin Qiongfang
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  4. Jin Xiaohai
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  5. Wang Shengcai
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Jinming, Z., Jiahe, T., Qiongfang, L. et al. Kinetic analysis of99mTc-d, 1-HMPAO decomposition and the method of stabilization. Journal of Radioanalytical and Nuclear Chemistry, Articles 206, 85–89 (1996). https://doi.org/10.1007/BF02040045

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  • DOI: https://doi.org/10.1007/BF02040045

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