Kinetic analysis of99mTc-d, 1-HMPAO decomposition and the method of stabilization

  • Zhang Jinming
  • Tian Jiahe
  • Lin Qiongfang
  • Jin Xiaohai
  • Wang Shengcai
Radiopharmaceuticals, Labelled Compounds and RIA

Abstract

The kinetics of99mTc-d, 1-HMPAO decomposition is studied using home kits. The results showed that99mTc-d, 1-HMPAO decomposition is a first-order reaction. The decomposition constant k is found to be 0.017±0.007h−1 under the experimental conditions of 20°C, 185MBq/ml, pH 7.0. The stability of99mTc-d, 1-HMPAO is affected not only by pH and radioactive concentration, but also by temperature. Using Immol/l gentisic acid as a stabilizer, 740MBq/ml of99mTc-d, 1-HMPAO can be stabilized for 3h with the radiochemical purity above 80%.

Keywords

Physical Chemistry Inorganic Chemistry Kinetic Analysis Radiochemical Purity Radioactive Concentration 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    R. D. NEIRINCKX, L. R. CANNING, I. M. PIPER, J. Nucl. Med., 28 (1987) 191.PubMedGoogle Scholar
  2. 2.
    C. H. KAO, K. S. HSIEH, Y. L. WANG Nucl. Med. Commun., 12 (1991) 951.PubMedGoogle Scholar
  3. 3.
    N. V. RAZUMENIC, N. PUJIC, N. DEDOVIC, Nucl. Med. Biol., 19 (1992) 251.Google Scholar
  4. 4.
    V. J. EYNE, A. FORSTER, D. A. TYRRELL, Nucl. Med. Commun., 10 (1989) 29.PubMedGoogle Scholar
  5. 5.
    J. C. HUNG, C. MELVIN, W. A. VOLKERT, Nucl. Med., 29 (1988) 1568.Google Scholar
  6. 6.
    J. C. HUNG, W. A. VOLKERT, R. A. HOLMES, Nucl. Med. Biol., 16 (1989) 675.Google Scholar
  7. 7.
    S. JURISSON, E. O. SCHLEMPER, D. E. TROUTNER, Inorg. Chem., 25 (1986) 543.Google Scholar
  8. 8.
    K. TUBERGEN, M. CORLIJA, W. A. VOLKERT, J. Nucl. Med., 32 (1991) 111.PubMedGoogle Scholar
  9. 9.
    A. TOFE, J. BEVAN, M. B. FAWZI, J. Nucl. Med., 21 (1980) 366.PubMedGoogle Scholar
  10. 10.
    J. LANG, E. BATBARICS, J. LAZAR, Eur. J. Nucl. Med., 16 (1989) 424.Google Scholar

Copyright information

© Akadémiai Kiadó 1996

Authors and Affiliations

  • Zhang Jinming
    • 1
  • Tian Jiahe
    • 1
  • Lin Qiongfang
    • 2
  • Jin Xiaohai
    • 2
  • Wang Shengcai
    • 1
  1. 1.Chinese PLA General HospitalsBeijing(P.R. China)
  2. 2.China Institute of Atomic EnergyBeijing(P. R. China)

Personalised recommendations