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Preparation, characterization and biodistribution of salicylidene- and pyridoxylidene-thyroxine complexes of technetium-99m

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Abstract

New Schiff bases, salicylidene- and pyridoxylidene-thyroxine have been prepared and characterized. They were labeled with99mTc. The labeling yield of the Schiff bases was over 95%. About 60% of the activity was bound to γ-globulin and albumin fractions when the labled compounds were incubated with a serum sample. The labeled compounds, after i.v. administration to rats, rapidly cleared from blood and excreted into the small intestine. They appeared to behave as hepatobiliary agents.

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Authors and Affiliations

  1. Pakistan Atomic Energy Commission (DNFM), P.O. Box 1114, Islamabad, (Pakistan)

    M. S. Iqbal

  2. Nuclear Chemistry Division, Pakistan Institute of Nuclear Science and Technology, P.O. Nilore, Islamabad, (Pakistan)

    M. H. Rizvi & A. Naqvi

Authors
  1. M. S. Iqbal
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  2. M. H. Rizvi
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  3. A. Naqvi
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Iqbal, M.S., Rizvi, M.H. & Naqvi, A. Preparation, characterization and biodistribution of salicylidene- and pyridoxylidene-thyroxine complexes of technetium-99m. Journal of Radioanalytical and Nuclear Chemistry, Articles 162, 139–144 (1992). https://doi.org/10.1007/BF02039934

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  • DOI: https://doi.org/10.1007/BF02039934

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