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Radiolabelling optimisation of 7-bromo-5-[123I]-iodo-4-oxo-1,4-dihidroquinoline-2-carboxylic acid: a potential tracer for NMDA SPECT studies

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Abstract

The synthesis of 7-bromo-5-[123I]-iodokynurenic acid is described. The tracer was prepared using a nucleophilic non-isotopic exchange reaction from the corresponding bromo derivative. Optimisation of the reaction parameters and HPLC purification were performed and the radiotracer was obtained in a chemical and radiochemical purity >95% and a specific activity of 235 Ci/μmol.

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Authors and Affiliations

  1. Department of Radiopharmacy, Faculty of Pharmaceutical Sciences, University of Ghent, Harelbekestraat 72, 9000, Ghent, Belgium

    F. Dumont & G. Slegers

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  1. F. Dumont
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  2. G. Slegers
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Dumont, F., Slegers, G. Radiolabelling optimisation of 7-bromo-5-[123I]-iodo-4-oxo-1,4-dihidroquinoline-2-carboxylic acid: a potential tracer for NMDA SPECT studies. J Radioanal Nucl Chem 218, 239–241 (1997). https://doi.org/10.1007/BF02039342

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  • DOI: https://doi.org/10.1007/BF02039342

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