Abstract
The yields for the loss of chromophore of Ni(II) and Cu(II) complexes of metronidazole,G(-Ni(II)M) andG(-Cu(II)M), reached almost zero when their aqueous solutions were γ-irradiated in the presence, of 0.4 mol·dm−3 of MeOH, EtOH,i-PrOH andt-BuOH in aerated medium. However, under N2O saturated conditions, these yields attained limiting values which suggests that the hydroxyalkyl radicals, derived from the alcohols by reaction with OH, react with the complexes in deaerated medium. But in aerated medium they react preferentially with O2. The rate constants for the reactions of the different hydroxyalkyl radicals with the complexes have been determined by the flash photolysis technique and the plausible mechanisms for the reactions have been suggested.
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J. C. ASQUITH, M. E. WATTS, K. PATEL, C. E. SMITH, G. E. ADAMS, Radiat. Res., 60 (1974) 108.
G. E. ADAMS, E. D. CLARKE, I. R. FLOCKHART, R. SJACOBS, I. J. STRATFORD, P. WARDMAN, M. E. WATTS, Int. J. Radiat. Biol., 35 (1979) 133.
J. L. FOSTER, R. L. WILLSON, Br. J. Radiol., 43 (1976) 234.
J. C. ASQUITH, J. L. FOSTER, R. L. WILLSON, R. M. INGS, J. A. Mc. PADZEAN, Br. J. Radiol. 47 (1974) 474.
B. A. MOORE, B. PALCIC, L. D. SKARSGARD, Radiat. Res., 67 (1976) 459.
E. J. HALL, ROIZIN-TOWELL, Radiology, 5, 177, 453.
N. P. FARREL, K. A. SKOV, J. Chem. Soc. Chem. Commun., (1987) 1043.
K. A. SKOV, N. P. FARREL, H. ADOMAT, Radiat. Res., 112 (1987) 273.
P. K. L. CHAN, K. A. SKOV, B. R. JAMES, N. P. FARREL, Int. J. Radiat. Oncol. Biol. Phys., 12 (1986) 1059.
K. A. SKOV, N. P. FARREL, Int. J. Radiat. Biol., 57 (1990) 947.
D. R. GRAHAM, D. S. SIGMAN, Inorg. Chem., 23 (1984) 4188.
S. GOLDSTEIN, G. CZAPSKI, J. Am. Chem. Soc., 108 (1986) 2244.
T. B. THEDERAHN, M. D. KUWALARA, T. A. LARSON, D. S. SIGMAN, J. Am. Chem. Soc., 111 (1989) 4941.
E. B. DOUBLE, R. C. RICHMOND, Int. J. Radiat, Oncol. Biol. Phys., 5 (1979) 1335.
W. A. CRAMP, Radiat. Res., 30 (1967) 221.
J. P. HESSLEWOOD, W. A. CRAMP, D. C. H. Mc. BRAIN, P. WILLIAMSON K. A. K. LOLT, Br. J. Cancer, Suppl. III, 37 (1978) 95.
M. BASU ROY, P. C. MANDAL, S. N. BHATTACHARYYA, J. Chem. Soc. Dalton Trans., 16 (1993) 2485.
P. C. MANDAL, D. K. BARDHAN, S. N. BHATTACHARYYA, Bull. Chem. Soc. Japan., 63 (1990) 2975.
D. J. EDWARDS, Biochem. Pharmac., 35 (1986) 53.
G. F. WHITMORE, A. J. VARGHESE, Biochem. Pharmac., 35 (1986) 97.
T. C. YEUNG, G. SUDLOW, R. L. KOCH, P. GOLDMAN, Biochem. Pharmac., 32 (1983) 2249.
A. I. VOGRL, A Textbook of Quantitative Inorganic Analysis, ELBS London, 1962, p. 784.
A. I. VOGRL, A Textbook of Quantitative Inorganic Analysis, ELBS London, 1962, p. 902.
J. L. WEELKS, M. S. MATHESON, J. Am. Chem. Soc., 78 (1956) 1273.
L. M. DORFMAN, G. E. ADAMS, in: Reactivity of the Hydroxyl Radicals in Aqueous Solutions, NSRDS-NBS-46, U. S. Department of Commerce, National Bureau Standards, Washington, D. C., 1973.
M. SIMIC, P. NETA, E. HAYON, J. Phys. Chem., 73 (1969) 1969.
I. G. DRAGANIC, Z. D. DRAGANIC, The Radiation Chemistry of Water, Academic Press, New York, p. 271.
D. E. MOORE, Int. J. Radiat. Biol., 51 (1987) 45.
D. W. WHILLANS, G. E. ADAMS, P. NETA, Radiat. Res., 62 (1975) 407.
E. GATTAVECCIA, D. TONELLI, A. BRECCIA, Int. J. Radiat. Biol. 42 (1982) 105.
W. A. MULAC, D. MEYERSTEIN, Inorg. Chem., 21 (1982) 1784.
M. Z. HOFFMAN, M. SIMIC, J. Am. Chem. Soc., 94 (1972) 1757.
P. WARDMAN, Int. J. Radiat. Biol., 28 (1975) 585.
P. WARDMAN, Life Chemistry Reports, 3 (1985) 22.
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Basu Roy, M., Mandal, P.C. & Bhattacharyya, S.N. Reactions of hydroxyalkyl radicals with nickel(II) and copper (II) complexes of 2-methyl-5-nitro-1H-imidazole-1-ethanol: A steady-state gamma-radiolysis and flash photolysis study. Journal of Radioanalytical and Nuclear Chemistry, Articles 191, 337–348 (1995). https://doi.org/10.1007/BF02038230
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DOI: https://doi.org/10.1007/BF02038230