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Paper and ITLC chromatography of99mTc radiopharmaceuticals: An explanation for some artefacts

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Abstract

Prevention of the tailing of99mTc-complexes in paper and ITLC chromatographic systems through understanding of the chemistry of this artefact is the aim of the study. Use of eluents with the same composition as the labeling medium of the complex, except tin, actually reduces the tailing. The effects of temperature and pH of the eluent on the phenomenon imply that the stability of the complex is its main determinant. Weakening of the complex by dilution in the normal saline eluent is followed by an interaction of the99mTc with the supporting medium or by a modification of the nature of99mTc (colloid formation). Unfortunately, if complexing eluents prevent the tailing and have no influence on the pertechnetate impurity, they are not suitable for routine quality control since reduced99mTc partially migrates in these systems.

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Authors and Affiliations

  1. Hôpital Erasme, Service des Radioisotopes, Cliniques Universitaires de Bruxelles, 808 route de Lennik, 1070, Bruxelles, (Belgium)

    B. Van Gansbeke & A. Schoutens

  2. Saint Pierre Hospital, Departments of Radioisotopes, Free University of Brussels, (Belgium)

    O. Jeghers & A. M. Ermans

Authors
  1. B. Van Gansbeke
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  2. O. Jeghers
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  3. A. M. Ermans
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  4. A. Schoutens
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Van Gansbeke, B., Jeghers, O., Ermans, A.M. et al. Paper and ITLC chromatography of99mTc radiopharmaceuticals: An explanation for some artefacts. Journal of Radioanalytical and Nuclear Chemistry, Articles 129, 33–41 (1989). https://doi.org/10.1007/BF02037566

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  • DOI: https://doi.org/10.1007/BF02037566

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