Sample validity in biological trace element and organic nutrient research studies

  • G. V. Iyengar
Sample Preparation


The complexities involved in dealing with the requirements of trace element research studies in the life sciences demand comprehensive planning of the investigations and use of a variety of techniques. It also requires a combination of biological insight and analytical awareness on the part of the investigators in order to obtain valid samples for analysis. Thus, the generation of meaningful conclusions from elemental composition studies on biological systems is a strictly multidisciplinary task, an approach that is vital for the overall success of the investigations. In addition, new initiatives are needed to produce multipurpose biological reference materials to cope with the growing demands of this multifaceted area of research. These aspects are discussed.


Physical Chemistry Inorganic Chemistry Reference Material Biological System Research Study 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    D. BEHNE, G. V. IYENGAR, Analytiker Taschenbuch, Springer Verlag, Berlin, 6 (1986) 237.Google Scholar
  2. 2.
    G. V. IYENGAR, W. E. KOLLMER, Trace Ele. Med., 3 (1986) 25.Google Scholar
  3. 3.
    G. V. IYENGAR, H. BORBERG, K. KASPEREK, J. KIEM, M. SIEGERS, L. E. FEINENDEGEN, R. GROSS, Clin. Chem. 25 (1979) 699.PubMedGoogle Scholar
  4. 4.
    G. V. IYENGAR, Anal. Chem., 54 (1982) 554A.Google Scholar
  5. 5.
    G. V. IYENGAR, NBS J. Res., 91 (1986) 67.Google Scholar
  6. 6.
    G. V. IYENGAR, J. Path., 134 (1981) 173.CrossRefPubMedGoogle Scholar
  7. 7.
    G. V. IYENGAR, 19th Annual Conference on Trace Substances in Environmental Health, D. D. Hemphill, Ed., University of Missouri, Columbia, 1985, p. 227.Google Scholar
  8. 8.
    R. H. SEASLY, in Reference 7,, p. 314.Google Scholar
  9. 9.
    D. BEHNE, J. Clin. Chem. Clin. Biochem., 19 (1981) 115.PubMedGoogle Scholar
  10. 10.
    R. M. PARR, in Reference 5,.Google Scholar
  11. 11.
    S. WISE, R. ZEISLER, Environ. Sci. Tech., 18 (1984) 302A.Google Scholar
  12. 12.
    M. STOEPPLER, Biological Reference Materials, W. R. WOLF (Eds.), John Wiley, New York, 1985, p. 281Google Scholar
  13. 13.
    Y. THOMASSEN, Oslo, Norway, 1985, personal communication.Google Scholar
  14. 14.
    L. FRIBERG, M. VAHTER, Environ. Res., 30 (1983) 95.CrossRefPubMedGoogle Scholar
  15. 15.
    B. LIND, C. G., ELINDER, L. FRIBERG, B. NILSSON, M. SVARTENGREN, M. VAHTER, 2nd International Workshop on Biological Reference. Materials, Neuherberg, April 24–25, 1986.Google Scholar
  16. 16.
    J. T. TANNER, J. S. SMITH, G. ANGYAL, P. W. DEFIBAUGH, M. C. VILLALOBOS, M. P. BUENO, J. A. O. A. C. 68 (1985) 1084.Google Scholar
  17. 17.
    C. VEILLON, S. A. LEWIS, K. Y. PATTERSON, W. R. WOLF, J. M. HARNLY, J. VERSIECK, L. VAN-BALLENBERGHE, R. CORNELIS, T. C. O'HAVER, Anal. Chem., 57 (1985) 2106.CrossRefPubMedGoogle Scholar
  18. 18.
    J. A. PENNINGTON, J. Am. Diet. Assoc., 829 (1983) 166.Google Scholar
  19. 19.
    G. V. IYENGAR, J. T. TANNER, W. R. WOLF, R. ZEISLER, Working Paper, 2nd RCM on Human Daily Dietary Intakes of Minor and Trace Elements determined by Nuclear and other Methods, IAEA, Vienna, April 15–18, (1986).Google Scholar
  20. 20.
    J. T. TANNER, J. S. SMITH, G. ANGYAL, P. W. DEFIBAUGH, M. C. VILLALOBOS, M. P. BUENO, G. V. IYENGAR, W. R. WOLF, R. ZEISLER, 2nd International Workshop on Biological Reference Materials, Neuherberg, April 24–25, 1986.Google Scholar

Copyright information

© Akadémiai Kiadó 1987

Authors and Affiliations

  • G. V. Iyengar
    • 1
  1. 1.NBSGaithersburg(USA)

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