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The role of neutron activation analysis and radioanalytical methods in dose-effect relationship studies for the setting of trace metal protection criteria

  • E. Sabbioni
  • R. Pietra
  • J. Edel
  • L. Goetz
Recent Developments

Abstract

In order to prepare scientifically accurate health protection criteria documents for trace metals integrated multidisciplinary research is necessary. In particular, the rational for structuring the documents should be based primarily on the two major questions of exposure and response. Unfortunately, in a majority of cases there is a paucity of relevant data to the establishment of dose-effect relationships. This work intends to show the role that neutron activation analysis and radiotracers with very high specific radioactivity have in solving problems relevant for establishing dose-effect relationships for trace metals. Typical applications in the different research areas involved in the preparation of the protection criteria, from source and exposure to levels and forms of trace metals in humans, are presented.

Keywords

Physical Chemistry Inorganic Chemistry Trace Metal Research Area Neutron Activation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    A. BERLIN, E. DI FERRANTE, La recherche à l'appui de la réglementation sur les métaux lourdes dans la Communauté Européenne in The Scientific Bases for Environmental Regulatory Action “Health Environment”, E. DI FERRANTE (Ed.), Rep. EUR 7952, CEC Luxembourg, 1982.Google Scholar
  2. 2.
    E. SABBIONI, Sci. Total Environ., 20 (1981) 95.CrossRefGoogle Scholar
  3. 3.
    E. SABBIONI, R. PIETRA, E. MARAFANTE, J. Radioanal. Chem., 69 (1982) 381.Google Scholar
  4. 4.
    E. SABBIONI, Radioactivation and radioactive tracer methods for research related to the protection of the environment and human health at the JRC-Ispra, ATOMKI Report C/3, MTA ATOMKI, 1985.Google Scholar
  5. 5.
    E. SABBIONI, R. PIETRA, G. RIZZATO, Multiple occupational exposure to heavy metals, Proc. 6th Convegno Nazionale di Igiene Industriale, 1st Int. Industriale Hygiene Conf., Rome, 5–7 December, Catholic University, Rome, 1983, p. 210.Google Scholar
  6. 6.
    E. SABBIONI, L. GOETZ, G. BIGNOLI, Sci. Total Environ., 40 (1981) 141.CrossRefGoogle Scholar
  7. 7.
    G. BIGNOLI, E. SABBIONI, Envir. Monit. Assess., 4 (1984) 53.CrossRefGoogle Scholar
  8. 8.
    D. R. DREESEN, E. S. GLADNEY, J. W. OWENS, B. L. PERKINS, C. L. WIENKE, L. E. WANGEN, Environ. Sci. Technol., 11 (1977) 1017.CrossRefGoogle Scholar
  9. 9.
    L. GOETZ, Water Sci. Technol., 15 (1983) 25.Google Scholar
  10. 10.
    W. D. JAMES, M. JANGHORBANI, T. BAXTER, Anal. Chem., 49 (1977) 1994.CrossRefGoogle Scholar
  11. 11.
    G. LUNDE, Env. Health Persp., 19 (1977) 47.Google Scholar
  12. 12.
    M. VAHTER, E. MARAFANTE, L. DENKER, Sci. Total Envir., 30 (1983) 197.CrossRefGoogle Scholar
  13. 13.
    K. HEYDORN, E. DAMSGAARD, N. A. LARSEN, B. NIELSEN, Sources of variability of trace element concentrations in human serum, Proc. of an Int. Symp. on Nuclear Activation Techniques in the Life Sciences, Vienna, 22–26 May 1978, IAEA, Vienna, 1979, p. 129.Google Scholar
  14. 14.
    E. SABBIONI, J. EDEL, L. GOETZ, Trace metal speciation in environmental toxicology research, Nutr. Res. Suppl. 1, 1985, p. 32.Google Scholar
  15. 15.
    G. K. H. TAM, S. M. CHARBONNEAU, F. BRYCE, E. SANDI, Bull. Environ. Contam. Toxicol., 28 (1982) 669.CrossRefPubMedGoogle Scholar

Copyright information

© Akadémiai Kiadó 1987

Authors and Affiliations

  • E. Sabbioni
    • 1
  • R. Pietra
    • 1
  • J. Edel
    • 1
  • L. Goetz
    • 1
  1. 1.Joint Research Centre-Ispra Establishment Radiochemistry DivisionCommission of the European CommunitiesIspra (VA)(Italy)

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