The role of neutron activation analysis and radioanalytical methods in dose-effect relationship studies for the setting of trace metal protection criteria
- 35 Downloads
In order to prepare scientifically accurate health protection criteria documents for trace metals integrated multidisciplinary research is necessary. In particular, the rational for structuring the documents should be based primarily on the two major questions of exposure and response. Unfortunately, in a majority of cases there is a paucity of relevant data to the establishment of dose-effect relationships. This work intends to show the role that neutron activation analysis and radiotracers with very high specific radioactivity have in solving problems relevant for establishing dose-effect relationships for trace metals. Typical applications in the different research areas involved in the preparation of the protection criteria, from source and exposure to levels and forms of trace metals in humans, are presented.
KeywordsPhysical Chemistry Inorganic Chemistry Trace Metal Research Area Neutron Activation
Unable to display preview. Download preview PDF.
- 1.A. BERLIN, E. DI FERRANTE, La recherche à l'appui de la réglementation sur les métaux lourdes dans la Communauté Européenne in The Scientific Bases for Environmental Regulatory Action “Health Environment”, E. DI FERRANTE (Ed.), Rep. EUR 7952, CEC Luxembourg, 1982.Google Scholar
- 3.E. SABBIONI, R. PIETRA, E. MARAFANTE, J. Radioanal. Chem., 69 (1982) 381.Google Scholar
- 4.E. SABBIONI, Radioactivation and radioactive tracer methods for research related to the protection of the environment and human health at the JRC-Ispra, ATOMKI Report C/3, MTA ATOMKI, 1985.Google Scholar
- 5.E. SABBIONI, R. PIETRA, G. RIZZATO, Multiple occupational exposure to heavy metals, Proc. 6th Convegno Nazionale di Igiene Industriale, 1st Int. Industriale Hygiene Conf., Rome, 5–7 December, Catholic University, Rome, 1983, p. 210.Google Scholar
- 9.L. GOETZ, Water Sci. Technol., 15 (1983) 25.Google Scholar
- 11.G. LUNDE, Env. Health Persp., 19 (1977) 47.Google Scholar
- 13.K. HEYDORN, E. DAMSGAARD, N. A. LARSEN, B. NIELSEN, Sources of variability of trace element concentrations in human serum, Proc. of an Int. Symp. on Nuclear Activation Techniques in the Life Sciences, Vienna, 22–26 May 1978, IAEA, Vienna, 1979, p. 129.Google Scholar
- 14.E. SABBIONI, J. EDEL, L. GOETZ, Trace metal speciation in environmental toxicology research, Nutr. Res. Suppl. 1, 1985, p. 32.Google Scholar