Determination of the natural level of human intra-thyroid iodine by instrumental neutron activation analysis

  • V. Ye. Zaichick
  • Yu. Ya. Choporov


The iodine thyroid content of 57 relatively healthy men and women 14–60 years old was studied using instrumental neutron activation analysis. Two methods were used: analysis of whole glands and the analysis of lyophilized samples weighing 50 mg each. Very good agreement between results was obtained. It was shown that the total iodine content, concentration and weight did not depend on age and sex. The typical mean thyroid parameters were found for healthy people of non-endemically goitrous regions where iodated food is not eaten. Average thyroid weight was 14.2g, iodine concentration was 350 μg/g of wet weight and thus total iodine content was 5 mg.


Inorganic Chemistry Iodine Instrumental Neutron Activation Analysis Healthy People Iodated 
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  1. 1.
    WERNER's The Thyroid. A Fundamental and Clinical Text, J. B. Lippincott Company, Philadelphia, 1986.Google Scholar
  2. 2.
    F. COTTINO, G. FREGOLA, G. ZOPPETTI, Annales Endocrinologie, 20 (1959) 445.Google Scholar
  3. 3.
    D. A. FISHER, T. H. ODDIE, J. Clin. Endocr., 29 (1969) 721.PubMedGoogle Scholar
  4. 4.
    G. B. BELLING, in: Trace Analysis of Biological Materials: Principles and Methods for Determination of Trace Elements, Elsevier, Amsterdam, 1988, p. 519.Google Scholar
  5. 5.
    A. M. ERMANS, J. E. DUMONT, P. A. BASTENIE, J. Clin. Endocr., 23 (1963) 539.Google Scholar
  6. 6.
    V. Ye. ZAICHICK, Yu. S. RYABUKHIN, A. V. TKACHEV, Med. Radiologiya, 4 (1968) 59 (in Russian).Google Scholar
  7. 7.
    Report of the Task Group on Reference Man, ICRP No. 23, Pergamon Press, Oxford, 1975.Google Scholar
  8. 8.
    H. KOLMITZ, R. E. REMINGTON, Endocrinology, 17 (1933) 563.Google Scholar
  9. 9.
    H. AGERBAEK, Acta Med. Scand., 196 (1974) 505.PubMedGoogle Scholar
  10. 10.
    P. HELLSTERN, H. E. KELLER, B. WEINHEIMER, H. WESCH, Clin. Endocrinology, 9 (1978) 351.Google Scholar
  11. 11.
    D. G. ROKHLIN, V. P. ZADVORNOVA, Ionizing Irradiation for Thyroid Cancer Diagnostics and Treatment, Meditsina, Leningrad, 1972.Google Scholar
  12. 12.
    K. IMAMURA, J. SASAKI, T. LJI, K. SOMEYA, M. FUJII, Radioisotopes, 26 (1977) 858.PubMedGoogle Scholar
  13. 13.
    J. PICKWORTH, J. Mental Sciences, (1925) 703.Google Scholar
  14. 14.
    GUTMAN, E. M. BENEDICT, B. BAXTER, W. W. PALMER, J. Biol. Chem., 98 (1932) 303.Google Scholar
  15. 15.
    V. S. MAYAT, I. M. SEGAL, A. M. FELDT, Sovetskaya Klinika, 17 (1932) 330 (in Russian).Google Scholar
  16. 16.
    W. ELMER, Fiziologia i Pathologia Przennany Jodu, Krakow, 1936.Google Scholar
  17. 17.
    H. LOHR, H. WILMANNS, H. SCHROEDER, Z. Gesamte Experimentelle Medizin, 109 (1941) 730.Google Scholar
  18. 18.
    E. KLEIN, D. REINWEIN, Acta Endocr. (Kbh), 41 (1962) 170.Google Scholar
  19. 19.
    K. E. AROSEIUS, Scand. J. Clin. Endocr., 16 (1964) 440.Google Scholar
  20. 20.
    P. A. HEEDMAN, B. JACOBSON, J. Clin. Endocr., 24 (1964) 246.PubMedGoogle Scholar
  21. 21.
    L. J. DeGROOT, J. Clin. Endocr., 26 (1965) 149.Google Scholar
  22. 22.
    A. COSTA, R. BACCI, M. CARLI, F. COTTINO, G. LISTTORTO, G. MAGRO, G. ZOPPETTI, Folia Endocrinologica, 20 (1967) 284.PubMedGoogle Scholar
  23. 23.
    W. H. BEIERWALTES, H. N. WAGNER, R. L. VOUGHT, A. T. MASI, in: Principles of Nuclear Medicine, W. B. Saunders, Philadelphia, 1968, p. 302.Google Scholar
  24. 24.
    R. A. McMAHON, M. L. M. PARKER, M. C. McKINNON, Med. J. Australia, 20 (1968) 210.Google Scholar
  25. 25.
    J. BRUNE, P. O. WESTER, Anal. Chim. Acta, 52 (1972) 81.CrossRefGoogle Scholar
  26. 26.
    N. JAMAGATA, T. JAMAGATA, J. Rad. Res., 13 (1972) 81.Google Scholar
  27. 27.
    W. T. BINNERTS, H. A. DAS, Methods Biochem. Anal., 22 (1974) 251.PubMedGoogle Scholar
  28. 28.
    L. KOSTA, V. ZELENKO, V. RAVNIK, M. LEVSTEK, M. DERMELI, A. R. BYRNE, in: Comparative Studies of Food and Environment Contamination, IAEA, Vienna, 1974, p. 541.Google Scholar
  29. 29.
    V. Ye. ZAICHICK, N. I. KONSTANTINOVA, N. P. ROSLYAKOV, L. K. NIKITENKO, in: Neutron Application in Medicine, Obninsk, 1976, p. 69 (in Russian).Google Scholar
  30. 30.
    L. L. OLIVER, R. V. BALLAD, O. K. MANUEL, Health Phys., 42 (1982) 425.PubMedGoogle Scholar
  31. 31.
    J. HANDL, A. PFAU, F. W. HUTH, Health Phys., 58 (1990) 609.PubMedGoogle Scholar
  32. 32.
    E. D. WILLIAMS, I. DONIACH, O. BJARNASON, W. MICHIE, Cancer, 39 (1977) 215.PubMedGoogle Scholar
  33. 33.
    S. THORESEN, E. GLATTRE, A. A. JOHANSEN, Tidsskr. Nor. Lageforen, 31 (1986) 2616.Google Scholar

Copyright information

© Akadémiai Kiadó 1996

Authors and Affiliations

  • V. Ye. Zaichick
    • 1
  • Yu. Ya. Choporov
    • 1
  1. 1.Medical Radiological Research Centre and Hospital Department of Forensic MedicineObninsk, Kaluga Region(Russia)

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