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Preparation of tritiated thymidine with high labelling yield via tritiated water

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Abstract

(6-3H)-Thymidine, (5-3H)-methyl-thymidine, and (5′-3H)-thymidine were synthesized by the use of tritiated water. The specific activities of the products were 3.3, 3.4 and 3.0 mCi/mM, respectively. These tritiated thymidines are important tracers to study human lymphocytes and human chromosomes.

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References

  1. J. VAN'T HOF, H. K. YING, Nature, 202 (1964) 981.

    PubMed  Google Scholar 

  2. F. N. HAYES, Int. J. Appl. Radiation Isotopes, 1 (1956) 46.

    Google Scholar 

  3. L. F. FIESER, M. FIESER, Reagents for Organic Synthesis, Vol. 1, John Wiley & Sons, London, 1967, p. 1140.

    Google Scholar 

  4. G. COATES, M. L. H. GREEN, K. WADE, Organometallic Compounds, Vol. 1, 3rd ed., Methuen, 1967.

  5. C. E. BORN, R. TAYLOR, J. Chem. Soc., (1961) 2388.

  6. G. HEVESY, E. Z. RONA, Phys. Chem., 89 (1915) 294.

    Google Scholar 

  7. G. HEVESY, L. T. ZECHMEISTER, Ber. Chem. Ges., 53 (1920) 410.

    Google Scholar 

  8. J. H. TAYLOR, P. S. WOODS, W. L. HUGHES, Proc. Natl. Acad. Sci. USA, 43 (1957) 122.

    Google Scholar 

  9. A. MURRAY, D. F. PETERSEN, F. N. HAYES, LAMP, 2627, 1961, p. 51.

    Google Scholar 

  10. L. A. CARPINO, J. Org. Chem., 35 (1970) 3971.

    Google Scholar 

  11. M. FETIZON, Tetrahedron, 29 (1973) 1011.

    Google Scholar 

  12. C. E. BORN, R. TAYLOR, J. Chem. Soc., (1960) 1480.

  13. A. I. VOGEL, Org. Synth., 32 (1957) 27.

    Google Scholar 

  14. A. I. VOGT, et al., Biopolymers, 1 (1963) 193.

    Google Scholar 

  15. E. A. EVANS et al.; unpublished results.

  16. E. A. EVANS, Tritium and its Compounds, Butterworths, London, 1974, p. 303.

    Google Scholar 

  17. J. ELVIDGE BLOXSIDGE, J. A. JONES, E. A. EVANS, Org. Mag. Res., 3 (1971) 127.

    Google Scholar 

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Authors and Affiliations

  1. Radioisotope Production Department, Nuclear Research Centre, P.O. Box 765, Baghdad, Iraq

    Y. F. Shafiq

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  1. Y. F. Shafiq
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Shafiq, Y.F. Preparation of tritiated thymidine with high labelling yield via tritiated water. Journal of Radioanalytical and Nuclear Chemistry, Articles 196, 113–123 (1995). https://doi.org/10.1007/BF02036295

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  • DOI: https://doi.org/10.1007/BF02036295

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