Journal of Radioanalytical and Nuclear Chemistry

, Volume 195, Issue 2, pp 263–270 | Cite as

Activation rates and chemical recovery of67Cu produced with low energy proton irradiation of enriched70Zn targets

  • D. J. sr Jamriska
  • W. A. Taylor
  • M. A. Ott
  • R. C. Heaton
  • D. R. Phillips
  • M. M. Fowler
Radiochemical and Miscellaneous Methods

Abstract

Copper-67 is a radioisotope with significant potential for diagnostic and therapeutic applications in nuclear medicine. Despite its promise,67Cu has failed to make an impact in clinical nuclear medicine, primarily because it is available sporadically, and in limited quantities. Common methods of production rely on high energy proton irradiation of natural zinc targets or on induced reactions using high energy neutrons at nuclear reactors. We have evaluated alternative production methods that could provide year-round adequate supply of this isotope. Using a low energy accelerator, we have studied the production of67Cu by proton reactions on enriched70Zn. Our results indicate that it is possible to produce useful quantities of67Cu from the irradiation of enriched70Zn with protons that have energies of less than 20 MeV. Production rates are higher than currently used methods at high energy accelerators or reactors. This isotope can be made available throughout the year as a result of this research.

Keywords

Nuclear Medicine Activation Rate Therapeutic Application Energy Neutron Adequate Supply 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    E. BROWNE, R. B. FIRESTONE, and V. S. SHIRLEY, Table of Radioactive Isotopes, John Wiley and Sons, New York, USA, (1986)Google Scholar
  2. 2.
    G. DE NARDO, S. DE NARDO, D. KUKUIS, H. DIRIL, C. SUEY, and C. MEARES, Int. J. Instrum. Part B, Nucl. Med. Biol. 18, (1992), 633Google Scholar
  3. 3.
    D. A. COLE, J. A. MERCER-SMITH, S. A. SCHREYER, J. K. NORMAN, and D. K. LAVALLEE, Nuc. Med. BIOl. 17, (1990), 457Google Scholar
  4. 4.
    D. A. COLE, D. C. MOODY, L. E. ELLINWOOD, M. G. KLEIN, J. A. MERCER-SMITH, A. BRUMBAUGH, R. O. EIKLEBERRY, D. LEWIS, G. SACCOMANNO, J. J. BECKTEL, and D. K. LAVALLEE, New Trends in Radiopharmaceutical Synthesis, Quality Assurance and Regulatory Control, (A. Emran, ed.) Plenum Press, New York, (1991), 109Google Scholar
  5. 5.
    J. A. MERCER-SMITH, J. C. ROBERTS, S. D. FIGARD, and D. K. LAVALLEE, Vol. 1 of Targeted Diagnosis and Therapy Series(J. T. Rodwell, ed.), Marcel Dekker, New York, (1988), 317Google Scholar
  6. 6.
    J. C. ROBERTS, S. D. FIGARD, J. A. MERCER-SMITH, Z. V. SVITRA, W. L. ANDERSON, and D. K. LAVALLEE, J. Immunol. Meth., 105, (1987), 153CrossRefGoogle Scholar
  7. 7.
    S. V. DESHPANDE, S. J. DE NARDO, C. F. MEARES, M. J. McCALL, G. P. ADAMS, M. K. MOI, and G. L. DE NARDO, J. Nucl. Med. 29, (1988), 217PubMedGoogle Scholar
  8. 8.
    S. MIRZADEH, F. F. KNAPP Jr., Radiochimica Acta, 57, (1992), 193Google Scholar
  9. 9.
    M. BLANN, J. BISPLINGHOFF, Code ALICE/Livermore 82. Lawrence Livermore National Laboratory-Internal Report UCID-19614, November 5, 1982.Google Scholar
  10. 10.
    J. F. ZIEGLER, J. P. BIERSACK, and V. LITTMARK, The Stopping and Range of Ions in Solids, Pergamon Press, Inc., New York, USA, (1985)Google Scholar
  11. 11.
    V. N. LEVKOVSKII, Activation Cross Section Nuclides of Average Masses(A=40-100) by Protons and Alpha-Particles with Average Energies (E=10-50 MeV), Moscow, Russia, (1991)Google Scholar
  12. 12.
    M. BARBIER, Induced Radioactivity, North Holland Publishing Co., Amsterdam-London, (1969)Google Scholar
  13. 13.
    S. MEGHIR, and L. YAFFE, Ph.D. Thesis, McGill University, Montreal, Quebec, Canada, (1962)Google Scholar
  14. 14.
    K. A. KRAUS, and F. NELSON, Proceedings of the International Conference on the Peaceful Uses of Atomic Energy, 1955, United Nations Vol. 7, (1956), 113Google Scholar
  15. 15.
    K. KOLSKY, p.c., Brookhaven National Laboratory, (1994)Google Scholar

Copyright information

© Akadémiai Kiadó 1995

Authors and Affiliations

  • D. J. sr Jamriska
    • 1
  • W. A. Taylor
    • 1
  • M. A. Ott
    • 1
  • R. C. Heaton
    • 1
  • D. R. Phillips
    • 1
  • M. M. Fowler
    • 1
  1. 1.Los Alamos National LaboratoryLos AlamosUSA

Personalised recommendations